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- W4385515565 abstract "Summary Ageing results from the gradual loss of homeostasis, and there are currently many hypotheses for the underlying initial causes, such as molecular damage accumulation. However, few if any theories directly connect comprehensive, underlying biological mechanisms to specific age-related diseases. We recently demonstrated how a specific maintenance system impeding overactivity disorders such as cancer might undergo positive selection while still resulting in a gradual homeostatic shift toward slower metabolism. Here we connect this metabolic slowdown, via a series of unavoidable homeostatic shifts, to the hallmarks of ageing, including mitochondrial dysfunction, insulin resistance (IR), weight gain, basal inflammation, and age-related diseases such as atherosclerosis. We constructed the fuel and energy model (FEM) based on these shifts and found that ageing via metabolic slowdown could explain not only the effects of anti-ageing interventions such as rapamycin and calorie restriction, but many of the paradoxes of ageing that currently defy alternative theories." @default.
- W4385515565 created "2023-08-04" @default.
- W4385515565 creator A5025975693 @default.
- W4385515565 creator A5029338507 @default.
- W4385515565 creator A5039442511 @default.
- W4385515565 creator A5051330244 @default.
- W4385515565 creator A5065699684 @default.
- W4385515565 date "2023-08-03" @default.
- W4385515565 modified "2023-09-27" @default.
- W4385515565 title "Metabolic slowdown as the proximal cause of ageing and death" @default.
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