FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385519633> ?p ?o ?g. }

• W4385519633 abstract "Abstract Bioelectricity is an understudied phenomenon to guide tissue homeostasis and regeneration. Conductive biomaterials may capture native or exogenous bioelectric signaling, but incorporation of conductive moieties is limited by cytotoxicity, poor injectability, or insufficient stimulation. Microgel annealed scaffolds are promising as hydrogel-based materials due to their inherent void space that facilitates cell migration and proliferation better than nanoporous bulk hydrogels. We generated conductive microgels from poly(ethylene) glycol and poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) to explore the interplay of void volume and conductivity on myogenic differentiation. PEDOT:PSS increased microgel conductivity over 2-fold while maintaining stiffness, annealing strength, and viability of associated myoblastic cells. C2C12 myoblasts exhibited increases in the late-stage differentiation marker myosin heavy chain as a function of both porosity and conductivity. Myogenin, an earlier marker, was influenced only by porosity. Human skeletal muscle derived cells exhibited increased Myod1 , IGF-1, and IGFBP-2 at earlier timepoints on conductive microgel scaffolds compared to non-conductive scaffolds. They also secreted higher levels of VEGF at early timepoints and expressed factors that led to macrophage polarization patterns observed during muscle repair. These data indicate that conductivity aids myogenic differentiation of myogenic cell lines and primary cells, motivating the need for future translational studies to promote muscle repair." @default.
• W4385519633 created "2023-08-04" @default.
• W4385519633 creator A5005576347 @default.
• W4385519633 creator A5018669549 @default.
• W4385519633 creator A5026661811 @default.
• W4385519633 creator A5029794580 @default.
• W4385519633 creator A5039095381 @default.
• W4385519633 creator A5081444299 @default.
• W4385519633 creator A5085637012 @default.
• W4385519633 date "2023-08-03" @default.
• W4385519633 modified "2023-09-27" @default.
• W4385519633 title "Conductive microgel annealed scaffolds enhance myogenic potential of myoblastic cells" @default.
• W4385519633 cites W1007294394 @default.
• W4385519633 cites W1562705858 @default.
• W4385519633 cites W1985617866 @default.
• W4385519633 cites W1987197433 @default.
• W4385519633 cites W2035210130 @default.
• W4385519633 cites W2042787641 @default.
• W4385519633 cites W2055492254 @default.
• W4385519633 cites W2066975869 @default.
• W4385519633 cites W2084482154 @default.
• W4385519633 cites W2100386453 @default.
• W4385519633 cites W2116635624 @default.
• W4385519633 cites W2337670939 @default.
• W4385519633 cites W2341057301 @default.
• W4385519633 cites W2441930534 @default.
• W4385519633 cites W2550134826 @default.
• W4385519633 cites W2572477750 @default.
• W4385519633 cites W2750958779 @default.
• W4385519633 cites W2902154203 @default.
• W4385519633 cites W2912094798 @default.
• W4385519633 cites W2922554959 @default.
• W4385519633 cites W2923545242 @default.
• W4385519633 cites W2940504419 @default.
• W4385519633 cites W2959863118 @default.
• W4385519633 cites W2969608693 @default.
• W4385519633 cites W2972043015 @default.
• W4385519633 cites W2982042951 @default.
• W4385519633 cites W2982656579 @default.
• W4385519633 cites W3042689819 @default.
• W4385519633 cites W3091995762 @default.
• W4385519633 cites W3095074479 @default.
• W4385519633 cites W3112497253 @default.
• W4385519633 cites W3156643349 @default.
• W4385519633 cites W3158345632 @default.
• W4385519633 cites W3189264138 @default.
• W4385519633 cites W3196497112 @default.
• W4385519633 cites W4200352330 @default.
• W4385519633 cites W4285005408 @default.
• W4385519633 cites W4312181585 @default.
• W4385519633 doi "https://doi.org/10.1101/2023.08.01.551533" @default.
• W4385519633 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37577583" @default.
• W4385519633 hasPublicationYear "2023" @default.
• W4385519633 type Work @default.
• W4385519633 citedByCount "0" @default.
• W4385519633 crossrefType "posted-content" @default.
• W4385519633 hasAuthorship W4385519633A5005576347 @default.
• W4385519633 hasAuthorship W4385519633A5018669549 @default.
• W4385519633 hasAuthorship W4385519633A5026661811 @default.
• W4385519633 hasAuthorship W4385519633A5029794580 @default.
• W4385519633 hasAuthorship W4385519633A5039095381 @default.
• W4385519633 hasAuthorship W4385519633A5081444299 @default.
• W4385519633 hasAuthorship W4385519633A5085637012 @default.
• W4385519633 hasBestOaLocation W43855196331 @default.
• W4385519633 hasConcept C108586683 @default.
• W4385519633 hasConcept C12554922 @default.
• W4385519633 hasConcept C136229726 @default.
• W4385519633 hasConcept C170029824 @default.
• W4385519633 hasConcept C171250308 @default.
• W4385519633 hasConcept C188027245 @default.
• W4385519633 hasConcept C192562407 @default.
• W4385519633 hasConcept C207200792 @default.
• W4385519633 hasConcept C2779227376 @default.
• W4385519633 hasConcept C3763915 @default.
• W4385519633 hasConcept C49892992 @default.
• W4385519633 hasConcept C60278653 @default.
• W4385519633 hasConcept C6997183 @default.
• W4385519633 hasConcept C71924100 @default.
• W4385519633 hasConcept C86803240 @default.
• W4385519633 hasConcept C95444343 @default.
• W4385519633 hasConceptScore W4385519633C108586683 @default.
• W4385519633 hasConceptScore W4385519633C12554922 @default.
• W4385519633 hasConceptScore W4385519633C136229726 @default.
• W4385519633 hasConceptScore W4385519633C170029824 @default.
• W4385519633 hasConceptScore W4385519633C171250308 @default.
• W4385519633 hasConceptScore W4385519633C188027245 @default.
• W4385519633 hasConceptScore W4385519633C192562407 @default.
• W4385519633 hasConceptScore W4385519633C207200792 @default.
• W4385519633 hasConceptScore W4385519633C2779227376 @default.
• W4385519633 hasConceptScore W4385519633C3763915 @default.
• W4385519633 hasConceptScore W4385519633C49892992 @default.
• W4385519633 hasConceptScore W4385519633C60278653 @default.
• W4385519633 hasConceptScore W4385519633C6997183 @default.
• W4385519633 hasConceptScore W4385519633C71924100 @default.
• W4385519633 hasConceptScore W4385519633C86803240 @default.
• W4385519633 hasConceptScore W4385519633C95444343 @default.
• W4385519633 hasLocation W43855196331 @default.
• W4385519633 hasLocation W43855196332 @default.
• W4385519633 hasLocation W43855196333 @default.
• W4385519633 hasOpenAccess W4385519633 @default.

• next