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- W4385542810 abstract "Systemic inflammation is linked to a range of neurological diseases. Reductions in cerebral blood flow (CBF) and the presence of brain hypoxia have been detected in animal models of inflammation and in multiple sclerosis, a disease with significant inflammation. Reduced CBF combined with hypoxia could exacerbate damage in neuroinflammatory conditions. To study this link, we used in-vivo 9.4T MRI to quantify CBF and R 2 * , a marker of deoxyhemoglobin, following systemic inflammation induced by bacterial lipopolysaccharide. We found reduced CBF and increased R 2 * in 4 regions, including the cortex and hippocampus—indicating that inflammation is accompanied by hypoxia and reduced CBF." @default.
- W4385542810 created "2023-08-04" @default.
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- W4385542810 date "2023-08-03" @default.
- W4385542810 modified "2023-09-27" @default.
- W4385542810 title "Systemic inflammation alters brain blood flow and R2*: An in-vivo 9.4T MRI animal study" @default.
- W4385542810 doi "https://doi.org/10.58530/2022/4848" @default.
- W4385542810 hasPublicationYear "2023" @default.
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