Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385543814> ?p ?o ?g. }
- W4385543814 endingPage "1285" @default.
- W4385543814 startingPage "1275" @default.
- W4385543814 abstract "Abstract In living cells, the 3D structure of gene loci is dynamic, but this is not revealed by 3C and FISH experiments in fixed samples, leaving a notable gap in our understanding. To overcome these limitations, we applied the highly predictive heteromorphic polymer (HiP-HoP) model to determine chromatin fiber mobility at the Pax6 locus in three mouse cell lines with different transcription states. While transcriptional activity minimally affects movement of 40-kbp regions, we observed that motion of smaller 1-kbp regions depends strongly on local disruption to chromatin fiber structure marked by H3K27 acetylation. This also substantially influenced locus configuration dynamics by modulating protein-mediated promoter-enhancer loops. Importantly, these simulations indicate that chromatin dynamics are sufficiently fast to sample all possible locus conformations within minutes, generating wide dynamic variability within single cells. This combination of simulation and experimental validation provides insight into how transcriptional activity influences chromatin structure and gene dynamics." @default.
- W4385543814 created "2023-08-04" @default.
- W4385543814 creator A5001134453 @default.
- W4385543814 creator A5030102907 @default.
- W4385543814 creator A5035473961 @default.
- W4385543814 creator A5036579745 @default.
- W4385543814 creator A5048945747 @default.
- W4385543814 creator A5062827068 @default.
- W4385543814 date "2023-08-03" @default.
- W4385543814 modified "2023-10-14" @default.
- W4385543814 title "Transcription modulates chromatin dynamics and locus configuration sampling" @default.
- W4385543814 cites W1831401007 @default.
- W4385543814 cites W1965863160 @default.
- W4385543814 cites W1973062929 @default.
- W4385543814 cites W1974223852 @default.
- W4385543814 cites W2007837658 @default.
- W4385543814 cites W2019465613 @default.
- W4385543814 cites W2046066026 @default.
- W4385543814 cites W2058306877 @default.
- W4385543814 cites W2088238021 @default.
- W4385543814 cites W2095955242 @default.
- W4385543814 cites W2103324856 @default.
- W4385543814 cites W2126406928 @default.
- W4385543814 cites W2150960435 @default.
- W4385543814 cites W2160216824 @default.
- W4385543814 cites W2162261678 @default.
- W4385543814 cites W2173155483 @default.
- W4385543814 cites W2196899564 @default.
- W4385543814 cites W2229187524 @default.
- W4385543814 cites W2320440892 @default.
- W4385543814 cites W2332009504 @default.
- W4385543814 cites W2395654621 @default.
- W4385543814 cites W2398215691 @default.
- W4385543814 cites W2401568148 @default.
- W4385543814 cites W2492174871 @default.
- W4385543814 cites W2564237126 @default.
- W4385543814 cites W2626627929 @default.
- W4385543814 cites W2734396477 @default.
- W4385543814 cites W2762780517 @default.
- W4385543814 cites W2785060777 @default.
- W4385543814 cites W2808847099 @default.
- W4385543814 cites W2825587407 @default.
- W4385543814 cites W2883604250 @default.
- W4385543814 cites W2898514070 @default.
- W4385543814 cites W2905576212 @default.
- W4385543814 cites W2917897282 @default.
- W4385543814 cites W2919496928 @default.
- W4385543814 cites W2948960930 @default.
- W4385543814 cites W2955885837 @default.
- W4385543814 cites W2968775930 @default.
- W4385543814 cites W2974792094 @default.
- W4385543814 cites W3002052930 @default.
- W4385543814 cites W3013167866 @default.
- W4385543814 cites W3016447954 @default.
- W4385543814 cites W3033286030 @default.
- W4385543814 cites W3035057809 @default.
- W4385543814 cites W3039137745 @default.
- W4385543814 cites W3098027661 @default.
- W4385543814 cites W3167143914 @default.
- W4385543814 cites W3202503277 @default.
- W4385543814 cites W4281703479 @default.
- W4385543814 cites W4286496229 @default.
- W4385543814 doi "https://doi.org/10.1038/s41594-023-01059-8" @default.
- W4385543814 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37537334" @default.
- W4385543814 hasPublicationYear "2023" @default.
- W4385543814 type Work @default.
- W4385543814 citedByCount "1" @default.
- W4385543814 countsByYear W43855438142023 @default.
- W4385543814 crossrefType "journal-article" @default.
- W4385543814 hasAuthorship W4385543814A5001134453 @default.
- W4385543814 hasAuthorship W4385543814A5030102907 @default.
- W4385543814 hasAuthorship W4385543814A5035473961 @default.
- W4385543814 hasAuthorship W4385543814A5036579745 @default.
- W4385543814 hasAuthorship W4385543814A5048945747 @default.
- W4385543814 hasAuthorship W4385543814A5062827068 @default.
- W4385543814 hasBestOaLocation W43855438141 @default.
- W4385543814 hasConcept C104317684 @default.
- W4385543814 hasConcept C111936080 @default.
- W4385543814 hasConcept C138885662 @default.
- W4385543814 hasConcept C179926584 @default.
- W4385543814 hasConcept C41895202 @default.
- W4385543814 hasConcept C54355233 @default.
- W4385543814 hasConcept C70721500 @default.
- W4385543814 hasConcept C83640560 @default.
- W4385543814 hasConcept C84597430 @default.
- W4385543814 hasConcept C86339819 @default.
- W4385543814 hasConcept C86803240 @default.
- W4385543814 hasConcept C93946551 @default.
- W4385543814 hasConcept C95444343 @default.
- W4385543814 hasConceptScore W4385543814C104317684 @default.
- W4385543814 hasConceptScore W4385543814C111936080 @default.
- W4385543814 hasConceptScore W4385543814C138885662 @default.
- W4385543814 hasConceptScore W4385543814C179926584 @default.
- W4385543814 hasConceptScore W4385543814C41895202 @default.
- W4385543814 hasConceptScore W4385543814C54355233 @default.
- W4385543814 hasConceptScore W4385543814C70721500 @default.
- W4385543814 hasConceptScore W4385543814C83640560 @default.
- W4385543814 hasConceptScore W4385543814C84597430 @default.