FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385543964> ?p ?o ?g. }

• W4385543964 endingPage "3953" @default.
• W4385543964 startingPage "3953" @default.
• W4385543964 abstract "Hypoxia leads to changes in tumor microenvironment (upregulated CAFs) with resultant aggressiveness. A key factor in the physiological response to hypoxia is hypoxia-inducible factor-1alpha (HIF-1α). [68Ga]Ga-FAPI PET imaging has been demonstrated in various cancer types. We hypothesized that [68Ga]Ga-FAPI PET may be used as an indirect tracer for mapping hypoxia by correlating the image findings to pathological analysis of HIF-1α expression. The [68Ga]Ga-FAPI PET/CT scans of women with cancer of the cervix were reviewed and the maximum and mean standardized uptake value (SUVmax and SUVmean) and FAPI tumor volume (FAPI-TV) were documented. Correlation analysis was performed between PET-derived parameters and immunohistochemical staining as well as between PET-derived parameters and the presence of metastasis. Ten women were included. All patients demonstrated tracer uptake in the primary site or region of the primary. All patients had lymph node metastases while only six patients had distant visceral or skeletal metastases. The mean SUVmax, SUVmean, and FAPI-TV was 18.89, 6.88, and 195.66 cm3, respectively. The average FAPI-TV for patients with additional sites of metastases was higher than those without. Immunohistochemistry revealed varying intensities of HIF-1α expression in all tested samples. There was a positive correlation between the presence of skeletal metastases and staining for HIF-1α (r=0.80;p=0.017). The presence of skeletal metastasis was correlated to the HIF-1⍺ staining (percentage distribution). Furthermore, the FAPI-TV was a better predictor of metastatic disease than the SUVmax." @default.
• W4385543964 created "2023-08-04" @default.
• W4385543964 creator A5003840634 @default.
• W4385543964 creator A5008293723 @default.
• W4385543964 creator A5023602417 @default.
• W4385543964 creator A5029014575 @default.
• W4385543964 creator A5035484134 @default.
• W4385543964 creator A5035797686 @default.
• W4385543964 creator A5035880944 @default.
• W4385543964 creator A5035960100 @default.
• W4385543964 creator A5045912194 @default.
• W4385543964 creator A5057397331 @default.
• W4385543964 creator A5063488694 @default.
• W4385543964 creator A5066767510 @default.
• W4385543964 creator A5067342192 @default.
• W4385543964 creator A5092591234 @default.
• W4385543964 date "2023-08-03" @default.
• W4385543964 modified "2023-09-30" @default.
• W4385543964 title "Correlation between [68Ga]Ga-FAPI-46 PET Imaging and HIF-1α Immunohistochemical Analysis in Cervical Cancer: Proof-of-Concept" @default.
• W4385543964 cites W1506063096 @default.
• W4385543964 cites W1885132804 @default.
• W4385543964 cites W1968597302 @default.
• W4385543964 cites W2028895886 @default.
• W4385543964 cites W2036463953 @default.
• W4385543964 cites W2069518226 @default.
• W4385543964 cites W2074402761 @default.
• W4385543964 cites W2093630931 @default.
• W4385543964 cites W2096076739 @default.
• W4385543964 cites W2110355766 @default.
• W4385543964 cites W2153895029 @default.
• W4385543964 cites W2168021523 @default.
• W4385543964 cites W2347046090 @default.
• W4385543964 cites W2725205340 @default.
• W4385543964 cites W2756233751 @default.
• W4385543964 cites W2789637558 @default.
• W4385543964 cites W2794164629 @default.
• W4385543964 cites W2811301438 @default.
• W4385543964 cites W2887241162 @default.
• W4385543964 cites W2892500138 @default.
• W4385543964 cites W2911949455 @default.
• W4385543964 cites W2913062750 @default.
• W4385543964 cites W2921316612 @default.
• W4385543964 cites W2930582547 @default.
• W4385543964 cites W2932807328 @default.
• W4385543964 cites W2963176372 @default.
• W4385543964 cites W2981226229 @default.
• W4385543964 cites W3010970122 @default.
• W4385543964 cites W3026198184 @default.
• W4385543964 cites W3034163420 @default.
• W4385543964 cites W3046837474 @default.
• W4385543964 cites W3128650343 @default.
• W4385543964 cites W3130668667 @default.
• W4385543964 cites W3137217418 @default.
• W4385543964 cites W3164206095 @default.
• W4385543964 cites W3173856189 @default.
• W4385543964 cites W3184735568 @default.
• W4385543964 cites W3201721517 @default.
• W4385543964 cites W4200583991 @default.
• W4385543964 cites W4210420917 @default.
• W4385543964 cites W4213098669 @default.
• W4385543964 cites W4220943328 @default.
• W4385543964 cites W4283737548 @default.
• W4385543964 cites W4284884855 @default.
• W4385543964 cites W4285097172 @default.
• W4385543964 cites W4310773966 @default.
• W4385543964 cites W4313642763 @default.
• W4385543964 cites W4313892623 @default.
• W4385543964 cites W4317107582 @default.
• W4385543964 doi "https://doi.org/10.3390/cancers15153953" @default.
• W4385543964 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37568769" @default.
• W4385543964 hasPublicationYear "2023" @default.
• W4385543964 type Work @default.
• W4385543964 citedByCount "0" @default.
• W4385543964 crossrefType "journal-article" @default.
• W4385543964 hasAuthorship W4385543964A5003840634 @default.
• W4385543964 hasAuthorship W4385543964A5008293723 @default.
• W4385543964 hasAuthorship W4385543964A5023602417 @default.
• W4385543964 hasAuthorship W4385543964A5029014575 @default.
• W4385543964 hasAuthorship W4385543964A5035484134 @default.
• W4385543964 hasAuthorship W4385543964A5035797686 @default.
• W4385543964 hasAuthorship W4385543964A5035880944 @default.
• W4385543964 hasAuthorship W4385543964A5035960100 @default.
• W4385543964 hasAuthorship W4385543964A5045912194 @default.
• W4385543964 hasAuthorship W4385543964A5057397331 @default.
• W4385543964 hasAuthorship W4385543964A5063488694 @default.
• W4385543964 hasAuthorship W4385543964A5066767510 @default.
• W4385543964 hasAuthorship W4385543964A5067342192 @default.
• W4385543964 hasAuthorship W4385543964A5092591234 @default.
• W4385543964 hasBestOaLocation W43855439641 @default.
• W4385543964 hasConcept C121608353 @default.
• W4385543964 hasConcept C126322002 @default.
• W4385543964 hasConcept C127077266 @default.
• W4385543964 hasConcept C142724271 @default.
• W4385543964 hasConcept C178790620 @default.
• W4385543964 hasConcept C185592680 @default.
• W4385543964 hasConcept C199374082 @default.
• W4385543964 hasConcept C204232928 @default.
• W4385543964 hasConcept C2775842073 @default.

• next