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- W4385544982 abstract "Employing mouse models of radiation necrosis (one that displays the histologic hallmarks of the clinical condition) and glioblastoma (GL261), deuterium ( 2 H) MR spectroscopy, in concert with infusion of 2 H-labelled glucose, was employed to ascertain whether the 2 H MRS signatures could differentiate the two lesions, an unmet clinical need. The 2 H MR metabolic profiles of the two lesions were markedly different. In the tumor, the Warburg effect (aerobic glycolysis, fermentation) converted glucose nearly exclusively to lactate. In radiation necrosis, oxidative phosphorylation (respiration) dominated, with glucose converting to TCA cycle intermediates glutamate and glutamine. Thus, 2 H MR distinguishes glioblastoma vs. radiation necrosis." @default.
- W4385544982 created "2023-08-04" @default.
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- W4385544982 date "2023-08-03" @default.
- W4385544982 modified "2023-09-27" @default.
- W4385544982 title "Deuterium (2H) MR Spectroscopy Distinguishes Tumor (Glioblastoma) from Radiation Necrosis in Mouse Brain" @default.
- W4385544982 doi "https://doi.org/10.58530/2022/3427" @default.
- W4385544982 hasPublicationYear "2023" @default.
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