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- W4385545789 endingPage "12377" @default.
- W4385545789 startingPage "12377" @default.
- W4385545789 abstract "DNA double-strand breaks (DSBs) are a significant threat to cell viability due to the induction of genome instability and the potential loss of genetic information. One of the key players for early DNA damage response is the conserved Mre11/Rad50 Nbs1/Xrs2 (MRN/X) complex, which is quickly recruited to the DNA’s ruptured ends and is required for their tethering and their subsequent repair via different pathways. The MRN/X complex associates with several other proteins to exert its functions, but it also exploits sophisticated internal dynamic properties to orchestrate the several steps required to address the damage. In this review, we summarize the intrinsic molecular features of the MRN/X complex through biophysical, structural, and computational analyses in order to describe the conformational transitions that allow for this complex to accomplish its multiple functions." @default.
- W4385545789 created "2023-08-04" @default.
- W4385545789 creator A5020481807 @default.
- W4385545789 creator A5050232933 @default.
- W4385545789 date "2023-08-03" @default.
- W4385545789 modified "2023-10-17" @default.
- W4385545789 title "Dynamic Properties of the DNA Damage Response Mre11/Rad50 Complex" @default.
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- W4385545789 doi "https://doi.org/10.3390/ijms241512377" @default.
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