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- W4385548151 abstract "The exact mechanisms that govern clonal dynamics and selection during early tumorigenesis remain largely elusive. Ceresa et al. provide experimental and mathematical evidence that MYC-dependent competition between individual clones is one driving force of brain tumor evolution, adding a winner/loser aspect to the picture that complements existing concepts. The exact mechanisms that govern clonal dynamics and selection during early tumorigenesis remain largely elusive. Ceresa et al. provide experimental and mathematical evidence that MYC-dependent competition between individual clones is one driving force of brain tumor evolution, adding a winner/loser aspect to the picture that complements existing concepts. Early clonal extinction in glioblastoma progression revealed by genetic barcodingCeresa et al.Cancer CellAugust 3, 2023In BriefCeresa et al. reveal that in the early stages of glioma development, intercellular competition results in a massive extinction event, annihilating most initial cancer cell clones. The study showed that the competition is driven by the expression of Myc gene and its targets. Full-Text PDF Open Access" @default.
- W4385548151 created "2023-08-04" @default.
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- W4385548151 date "2023-08-01" @default.
- W4385548151 modified "2023-10-17" @default.
- W4385548151 title "The winner takes it all: Competition drives clonal selection in gliomagenesis" @default.
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- W4385548151 doi "https://doi.org/10.1016/j.ccell.2023.07.003" @default.
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