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- W4385549063 abstract "The ubiquitous coexistence of the redox cofactors NADH and NADPH is widely considered to facilitate an efficient operation of cellular redox metabolism. However, it remains unclear what shapes the NAD(P)H specificity of specific redox reactions. Here, we present a computational framework to analyze the effect of redox cofactor swaps on the maximal thermodynamic potential of a metabolic network and use it to investigate key aspects of redox cofactor redundancy in Escherichia coli. As one major result, our analysis suggests that evolved NAD(P)H specificities are largely shaped by metabolic network structure and associated thermodynamic constraints enabling thermodynamic driving forces that are close or even identical to the theoretical optimum and significantly higher compared to random specificities. Furthermore, while redundancy of NAD(P)H is clearly beneficial for thermodynamic driving forces, a third redox cofactor would require a low standard redox potential to be advantageous. Our approach also predicts trends of redox-cofactor concentration ratios and could facilitate the design of optimal redox cofactor specificities." @default.
- W4385549063 created "2023-08-04" @default.
- W4385549063 creator A5024811098 @default.
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- W4385549063 date "2023-08-03" @default.
- W4385549063 modified "2023-09-26" @default.
- W4385549063 title "Network-wide thermodynamic constraints shape NAD(P)H cofactor specificity of biochemical reactions" @default.
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- W4385549063 doi "https://doi.org/10.1038/s41467-023-40297-8" @default.
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