FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385549323> ?p ?o ?g. }

• W4385549323 endingPage "29835" @default.
• W4385549323 startingPage "29812" @default.
• W4385549323 abstract "Pesticides are widely used, resulting in continuing human exposure with potential health impacts. Some exposures related to agricultural works have been associated with neurological disorders. Since the 2000s, the hypothesis of the role of pesticides in the occurrence of central nervous system (CNS) tumors has been better documented in the literature. However, the etiology of childhood brain cancers still remains largely unknown. The major objective of this work was to assess the potential role of pesticide exposure as a risk factor for CNS tumors based on questionnaires and statistical analysis of information collected from patients hospitalized in the Neurosurgery Department of the Habib Bourguiba Hospital Medium in Sfax, Tunisia, during the period from January 1, 2022, to May 31, 2023. It also aimed to develop a simple and rapid analytical method by the gas chromatography-mass spectrometry technique for the research traces of pesticide metabolites in some collected human brain tumor tissues in order to more emphasize our hypothesis for such a correlation between pesticide exposure and brain tumor development. Patients with a history of high-risk exposure were selected to conduct further analysis. Chemometric methods were adapted to discern intrinsic variation between pathological and control groups and ascertain effective separation with the identification of differentially expressed metabolites accountable for such variations. Three samples revealed traces of pesticide metabolites that were mostly detected at an early age. The histopathological diagnosis was medulloblastoma for a 10-year-old child and high-grade gliomas for 27- and 35-year-old adults. The bivariate analyses (odds ratio >1 and P value <5%) confirmed the great probability of developing cancer by an exposure case. The Cox proportional hazards model revealed the risk of carcinogenicity beyond the age of 50 as a long-term effect of pesticide toxicity. Our study supports the correlation between pesticide exposure and the risk of development of human brain tumors, suggesting that preconception pesticide exposure, and possibly exposure during pregnancy, is associated with an increased childhood brain tumor risk. This hypothesis was enhanced in identifying traces of metabolites from the carbamate insecticide class known for their neurotoxicity and others from pyridazinone, organochlorines (OCs), triazole fungicide, and N-nitroso compounds known for their carcinogenicity. The 2D-OXYBLOT analysis confirmed the neurotoxicity effect of insecticides to induce oxidative damage in CNS cells. Aldicarb was implicated in brain carcinogenicity confirmed by the identification of oxime metabolites in a stress degradation study. Revealing aziridine metabolites from the OC class may better emphasize the theory of detecting traces of pesticide metabolites at an early age. Overall, our findings lead to the recommendation of limiting the residential use of pesticides and the support of public health policies serving this objective that we need to be vigilant in the postmarketing surveillance of human health impacts." @default.
• W4385549323 created "2023-08-04" @default.
• W4385549323 creator A5000566005 @default.
• W4385549323 creator A5000959135 @default.
• W4385549323 creator A5007143857 @default.
• W4385549323 creator A5008066160 @default.
• W4385549323 creator A5010397991 @default.
• W4385549323 creator A5017238912 @default.
• W4385549323 creator A5018825101 @default.
• W4385549323 creator A5035755122 @default.
• W4385549323 creator A5039647721 @default.
• W4385549323 creator A5051679568 @default.
• W4385549323 creator A5056332452 @default.
• W4385549323 creator A5069180703 @default.
• W4385549323 creator A5080558774 @default.
• W4385549323 creator A5085349299 @default.
• W4385549323 creator A5088455213 @default.
• W4385549323 creator A5092592198 @default.
• W4385549323 date "2023-08-03" @default.
• W4385549323 modified "2023-10-17" @default.
• W4385549323 title "Research of Pesticide Metabolites in Human Brain Tumor Tissues by Chemometrics-Based Gas Chromatography–Mass Spectrometry Analysis for a Hypothetical Correlation between Pesticide Exposure and Risk Factor of Central Nervous System Tumors" @default.
• W4385549323 cites W117085007 @default.
• W4385549323 cites W1211507196 @default.
• W4385549323 cites W1504584187 @default.
• W4385549323 cites W1533106703 @default.
• W4385549323 cites W1597643123 @default.
• W4385549323 cites W1819333883 @default.
• W4385549323 cites W1830535040 @default.
• W4385549323 cites W1866553754 @default.
• W4385549323 cites W1911608194 @default.
• W4385549323 cites W1965189813 @default.
• W4385549323 cites W1968242429 @default.
• W4385549323 cites W1975828755 @default.
• W4385549323 cites W1978044610 @default.
• W4385549323 cites W1979368709 @default.
• W4385549323 cites W1979695433 @default.
• W4385549323 cites W1982929051 @default.
• W4385549323 cites W1999749496 @default.
• W4385549323 cites W2002940154 @default.
• W4385549323 cites W2007649442 @default.
• W4385549323 cites W2009454719 @default.
• W4385549323 cites W2012034827 @default.
• W4385549323 cites W2013426884 @default.
• W4385549323 cites W2014640202 @default.
• W4385549323 cites W2022673360 @default.
• W4385549323 cites W2026915927 @default.
• W4385549323 cites W2027004104 @default.
• W4385549323 cites W2027261969 @default.
• W4385549323 cites W2032555174 @default.
• W4385549323 cites W2033928841 @default.
• W4385549323 cites W2034138274 @default.
• W4385549323 cites W2039745399 @default.
• W4385549323 cites W2040034560 @default.
• W4385549323 cites W2048966030 @default.
• W4385549323 cites W2050856974 @default.
• W4385549323 cites W2051264316 @default.
• W4385549323 cites W2052925329 @default.
• W4385549323 cites W2059643569 @default.
• W4385549323 cites W2060087728 @default.
• W4385549323 cites W2065091484 @default.
• W4385549323 cites W2066467215 @default.
• W4385549323 cites W2067776630 @default.
• W4385549323 cites W2069316581 @default.
• W4385549323 cites W2070066327 @default.
• W4385549323 cites W2079709853 @default.
• W4385549323 cites W2081320593 @default.
• W4385549323 cites W2083820071 @default.
• W4385549323 cites W2084485296 @default.
• W4385549323 cites W2087283602 @default.
• W4385549323 cites W2087726533 @default.
• W4385549323 cites W2092312109 @default.
• W4385549323 cites W2094843919 @default.
• W4385549323 cites W2097620122 @default.
• W4385549323 cites W2098507802 @default.
• W4385549323 cites W2101487994 @default.
• W4385549323 cites W2102666880 @default.
• W4385549323 cites W2106525632 @default.
• W4385549323 cites W2107919301 @default.
• W4385549323 cites W2115239996 @default.
• W4385549323 cites W2124488275 @default.
• W4385549323 cites W2126609554 @default.
• W4385549323 cites W2129836734 @default.
• W4385549323 cites W2131111598 @default.
• W4385549323 cites W2136776712 @default.
• W4385549323 cites W2146797438 @default.
• W4385549323 cites W2147539510 @default.
• W4385549323 cites W2150430982 @default.
• W4385549323 cites W2153708719 @default.
• W4385549323 cites W2154789444 @default.
• W4385549323 cites W2166303459 @default.
• W4385549323 cites W2170107646 @default.
• W4385549323 cites W2190372016 @default.
• W4385549323 cites W2207931075 @default.
• W4385549323 cites W2276498563 @default.
• W4385549323 cites W2276644390 @default.
• W4385549323 cites W2283197772 @default.
• W4385549323 cites W2285723579 @default.
• W4385549323 cites W2289602271 @default.

• next