FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385549495> ?p ?o ?g. }

• W4385549495 abstract "The polysaccharides found in Cordyceps cicadae (C. cicadae) have received increasing academic attention owing to their wide variety of therapeutic activities.This study evaluated the hypoglycemic, antioxidant, and anti-inflammatory effects of polysaccharides from C. cicadae (CH-P). In addition, 16s rDNA sequencing and untargeted metabolomics analysis by liquid chromatography-mass spectrometry (LC-MS) were used to estimate the changes and regulatory relationships between gut microbiota and its metabolites. The fecal microbiota transplantation (FMT) was used to verify the therapeutic effects of microbial remodeling.The results showed that CH-P treatment displayed hypoglycemic, antioxidant, and anti-inflammatory effects and alleviated tissue damage induced by diabetes. The CH-P treatment significantly reduced the Firmicutes/Bacteroidetes ratio and increased the abundance of Bacteroides, Odoribacter, Alloprevotella, Parabacteroides, Mucispirillum, and significantly decreased the abundance of Helicobacter and Lactobacillus compared to the diabetic group. The alterations in the metabolic pathways were mostly related to amino acid biosynthesis and metabolic pathways (particularly those involving tryptophan) according to the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis. Correlation analysis showed that Bacteroides, Odoribacter, Alloprevotella, Parabacteroides, and Mucispirillum were positively correlated with indole and its derivatives, such as 5-hydroxyindole-3-acetic acid. Indole intervention significantly improved hyperglycemic symptoms and insulin sensitivity, and increased the secretion of glucagon-like peptide-1 (GLP-1) in diabetic mice. FMT reduced blood glucose levels, improved glucose tolerance, and increased insulin sensitivity in diabetic mice. However, FMT did not significantly improve GLP-1 levels.This indicates that C. cicadae polysaccharides alleviate hyperglycemia by regulating the production of metabolites other than indole and its derivatives by gut microbiota. This study provides an important reference for the development of novel natural products." @default.
• W4385549495 created "2023-08-04" @default.
• W4385549495 creator A5005157362 @default.
• W4385549495 creator A5018914115 @default.
• W4385549495 creator A5024415909 @default.
• W4385549495 creator A5025804419 @default.
• W4385549495 creator A5038100263 @default.
• W4385549495 creator A5038643381 @default.
• W4385549495 creator A5039135711 @default.
• W4385549495 creator A5042533031 @default.
• W4385549495 creator A5075838980 @default.
• W4385549495 date "2023-08-03" @default.
• W4385549495 modified "2023-09-26" @default.
• W4385549495 title "Cordyceps cicadae polysaccharides alleviate hyperglycemia by regulating gut microbiota and its mmetabolites in high-fat diet/streptozocin-induced diabetic mice" @default.
• W4385549495 cites W1919048856 @default.
• W4385549495 cites W1986014108 @default.
• W4385549495 cites W1999487199 @default.
• W4385549495 cites W2000671866 @default.
• W4385549495 cites W2011371686 @default.
• W4385549495 cites W2011995221 @default.
• W4385549495 cites W2042394891 @default.
• W4385549495 cites W2057433429 @default.
• W4385549495 cites W2065725792 @default.
• W4385549495 cites W2071841602 @default.
• W4385549495 cites W2077839600 @default.
• W4385549495 cites W2078815126 @default.
• W4385549495 cites W2082509173 @default.
• W4385549495 cites W2088986234 @default.
• W4385549495 cites W2095158284 @default.
• W4385549495 cites W2101223785 @default.
• W4385549495 cites W2106036385 @default.
• W4385549495 cites W2112931540 @default.
• W4385549495 cites W2115763995 @default.
• W4385549495 cites W2122836188 @default.
• W4385549495 cites W2150367899 @default.
• W4385549495 cites W2167062509 @default.
• W4385549495 cites W2209722659 @default.
• W4385549495 cites W2291548004 @default.
• W4385549495 cites W2299287477 @default.
• W4385549495 cites W2331944871 @default.
• W4385549495 cites W2414006046 @default.
• W4385549495 cites W2416808404 @default.
• W4385549495 cites W2461462491 @default.
• W4385549495 cites W2507513358 @default.
• W4385549495 cites W2570056041 @default.
• W4385549495 cites W2589953033 @default.
• W4385549495 cites W2599136492 @default.
• W4385549495 cites W2620744488 @default.
• W4385549495 cites W2790968719 @default.
• W4385549495 cites W2806350604 @default.
• W4385549495 cites W2807007381 @default.
• W4385549495 cites W2807728333 @default.
• W4385549495 cites W2884733592 @default.
• W4385549495 cites W2886401819 @default.
• W4385549495 cites W2892183154 @default.
• W4385549495 cites W2897498688 @default.
• W4385549495 cites W2897737816 @default.
• W4385549495 cites W2899100296 @default.
• W4385549495 cites W2905549630 @default.
• W4385549495 cites W2906742147 @default.
• W4385549495 cites W2925731938 @default.
• W4385549495 cites W2929044766 @default.
• W4385549495 cites W2955452112 @default.
• W4385549495 cites W2956018562 @default.
• W4385549495 cites W2997829654 @default.
• W4385549495 cites W3000152506 @default.
• W4385549495 cites W3008031857 @default.
• W4385549495 cites W3016928764 @default.
• W4385549495 cites W3018299274 @default.
• W4385549495 cites W3035353748 @default.
• W4385549495 cites W3037327788 @default.
• W4385549495 cites W3083892109 @default.
• W4385549495 cites W3107734125 @default.
• W4385549495 cites W3118955581 @default.
• W4385549495 cites W3119227315 @default.
• W4385549495 cites W3204883107 @default.
• W4385549495 cites W4211120413 @default.
• W4385549495 cites W4221009473 @default.
• W4385549495 cites W4221033726 @default.
• W4385549495 cites W4284714506 @default.
• W4385549495 cites W4296234534 @default.
• W4385549495 cites W4309632159 @default.
• W4385549495 cites W4309750444 @default.
• W4385549495 cites W4311522547 @default.
• W4385549495 cites W4313648726 @default.
• W4385549495 doi "https://doi.org/10.3389/fnut.2023.1203430" @default.
• W4385549495 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37599693" @default.
• W4385549495 hasPublicationYear "2023" @default.
• W4385549495 type Work @default.
• W4385549495 citedByCount "0" @default.
• W4385549495 crossrefType "journal-article" @default.
• W4385549495 hasAuthorship W4385549495A5005157362 @default.
• W4385549495 hasAuthorship W4385549495A5018914115 @default.
• W4385549495 hasAuthorship W4385549495A5024415909 @default.
• W4385549495 hasAuthorship W4385549495A5025804419 @default.
• W4385549495 hasAuthorship W4385549495A5038100263 @default.
• W4385549495 hasAuthorship W4385549495A5038643381 @default.
• W4385549495 hasAuthorship W4385549495A5039135711 @default.
• W4385549495 hasAuthorship W4385549495A5042533031 @default.
• W4385549495 hasAuthorship W4385549495A5075838980 @default.

• next