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- W4385551588 abstract "ABSTRACT Tissue fusion is a critical process that is repeated in multiple contexts during embryonic development and shares common attributes to processes such as wound healing and metastases. Ocular coloboma is a developmental eye disorder that presents as a physical gap in the ventral eye, and is a major cause of childhood blindness. Coloboma results from fusion failure between opposing ventral retinal epithelia, but there are major knowledge gaps in our understanding of this process at the molecular and cell behavioural levels. Here we catalogue the expression of cell adhesion proteins: N-cadherin, E-cadherin, ZO-1, and the EMT transcriptional activator and cadherin regulator SNAI2. We find that fusion pioneer cells at the edges of the fusing optic fissure have unique and dynamic expression profiles for N-cad, E-cad and ZO-1, and that these are temporally preceded by expression of SNAI2. This highlights the unique properties of these cells and indicates that regulation of cell adhesion factors is a critical process in optic fissure closure." @default.
- W4385551588 created "2023-08-04" @default.
- W4385551588 creator A5060493454 @default.
- W4385551588 creator A5063899891 @default.
- W4385551588 date "2023-08-02" @default.
- W4385551588 modified "2023-09-27" @default.
- W4385551588 title "Cell adhesion marker expression dynamics during fusion of the optic fissure" @default.
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- W4385551588 doi "https://doi.org/10.1101/2023.08.01.551419" @default.
- W4385551588 hasPublicationYear "2023" @default.
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