FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385551713> ?p ?o ?g. }

• W4385551713 endingPage "1274" @default.
• W4385551713 startingPage "1263" @default.
• W4385551713 abstract "The prevalence of mild cognitive impairment (MCI) in patients with type 2 diabetes (T2D) is rapidly increasing. Thyroid hormones are key regulators of cognitive function in adults. The purpose of this study was to investigate the relationship between thyroid hormone sensitivity and MCI in euthyroid T2D patients.A total of 400 euthyroid T2D patients were enrolled in this cross-sectional study, including 218 patients with normal cognition and 182 MCI patients. The Montreal Cognitive Assessment (MoCA) was used to evaluate cognitive function. The free triiodothyronine to free thyroxine (FT3/FT4) ratio was calculated as a measure of peripheral sensitivity to thyroid hormones; the thyroid-stimulating hormone index (TSHI), thyrotrophic thyroxine resistance index (TT4RI) and thyroid feedback quantile-based index (TFQI) were calculated as measures of central sensitivity to thyroid hormones. Linear regression analysis and logistic regression analysis were performed to explore the relationships between these indices of thyroid hormone sensitivity and the MoCA score and MCI, respectively.Compared with the normal cognitive function group, patients in the MCI group had higher TSHI, TT4RI and TFQI but a lower FT3/FT4 ratio (P<0.05). The MoCA score was positively correlated with the FT3/FT4 ratio but negatively correlated with TSHI, TT4RI and TFQI (P< 0.05). Multivariate logistic regression analysis showed that a low FT3/FT4 ratio and high TSHI, TT4RI and TFQI were independently associated with MCI (P<0.05). After adjustment for confounding factors, the odds ratio (OR) for the association between MCI and the highest tertile of the FT3/FT4 was 0.455 (95% CI: 0.264-0.785), for the highest tertile of TSHI, the OR was 2.380 (95% CI: 1.376-4.119), for the highest tertile of TT4RI, the OR was 2.342 (95% CI:1.353-4.054), and for the highest tertile of TFQI, the OR was 2.536 (95% CI: 1.466-4.387) (P< 0.05).Impaired sensitivity to thyroid hormones is associated with MCI in euthyroid T2D patients." @default.
• W4385551713 created "2023-08-04" @default.
• W4385551713 creator A5005412189 @default.
• W4385551713 creator A5051501156 @default.
• W4385551713 creator A5055675142 @default.
• W4385551713 creator A5073273338 @default.
• W4385551713 creator A5078326064 @default.
• W4385551713 creator A5083285885 @default.
• W4385551713 date "2023-08-01" @default.
• W4385551713 modified "2023-10-01" @default.
• W4385551713 title "Impaired Sensitivity to Thyroid Hormones is Associated with Mild Cognitive Impairment in Euthyroid Patients with Type 2 Diabetes" @default.
• W4385551713 cites W1840776978 @default.
• W4385551713 cites W1845614074 @default.
• W4385551713 cites W187997220 @default.
• W4385551713 cites W1989539075 @default.
• W4385551713 cites W1998120744 @default.
• W4385551713 cites W2019247935 @default.
• W4385551713 cites W2033937370 @default.
• W4385551713 cites W2051213750 @default.
• W4385551713 cites W2056985030 @default.
• W4385551713 cites W2083172499 @default.
• W4385551713 cites W2088469646 @default.
• W4385551713 cites W2090684932 @default.
• W4385551713 cites W2096162365 @default.
• W4385551713 cites W2115017507 @default.
• W4385551713 cites W2115369607 @default.
• W4385551713 cites W2124386285 @default.
• W4385551713 cites W2188679450 @default.
• W4385551713 cites W2337223424 @default.
• W4385551713 cites W2436745354 @default.
• W4385551713 cites W2472139364 @default.
• W4385551713 cites W2510081258 @default.
• W4385551713 cites W2520615418 @default.
• W4385551713 cites W2578175640 @default.
• W4385551713 cites W2582524520 @default.
• W4385551713 cites W2611024120 @default.
• W4385551713 cites W2774743973 @default.
• W4385551713 cites W2789887292 @default.
• W4385551713 cites W2804675788 @default.
• W4385551713 cites W2884234047 @default.
• W4385551713 cites W2891579449 @default.
• W4385551713 cites W2904867458 @default.
• W4385551713 cites W3003656531 @default.
• W4385551713 cites W3049551410 @default.
• W4385551713 cites W3135597971 @default.
• W4385551713 cites W3196299617 @default.
• W4385551713 cites W3198657567 @default.
• W4385551713 cites W3208769337 @default.
• W4385551713 cites W3217495642 @default.
• W4385551713 cites W4200089804 @default.
• W4385551713 cites W4210673430 @default.
• W4385551713 cites W4210965305 @default.
• W4385551713 cites W4226128740 @default.
• W4385551713 cites W4254965081 @default.
• W4385551713 cites W4283032324 @default.
• W4385551713 cites W4283720610 @default.
• W4385551713 cites W4284886605 @default.
• W4385551713 cites W4294926291 @default.
• W4385551713 cites W910436092 @default.
• W4385551713 doi "https://doi.org/10.2147/cia.s413584" @default.
• W4385551713 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37554512" @default.
• W4385551713 hasPublicationYear "2023" @default.
• W4385551713 type Work @default.
• W4385551713 citedByCount "2" @default.
• W4385551713 countsByYear W43855517132023 @default.
• W4385551713 crossrefType "journal-article" @default.
• W4385551713 hasAuthorship W4385551713A5005412189 @default.
• W4385551713 hasAuthorship W4385551713A5051501156 @default.
• W4385551713 hasAuthorship W4385551713A5055675142 @default.
• W4385551713 hasAuthorship W4385551713A5073273338 @default.
• W4385551713 hasAuthorship W4385551713A5078326064 @default.
• W4385551713 hasAuthorship W4385551713A5083285885 @default.
• W4385551713 hasBestOaLocation W43855517131 @default.
• W4385551713 hasConcept C126322002 @default.
• W4385551713 hasConcept C134018914 @default.
• W4385551713 hasConcept C151956035 @default.
• W4385551713 hasConcept C156957248 @default.
• W4385551713 hasConcept C2776632958 @default.
• W4385551713 hasConcept C2777180221 @default.
• W4385551713 hasConcept C2777195454 @default.
• W4385551713 hasConcept C2779134260 @default.
• W4385551713 hasConcept C2984915365 @default.
• W4385551713 hasConcept C2993291352 @default.
• W4385551713 hasConcept C526584372 @default.
• W4385551713 hasConcept C555293320 @default.
• W4385551713 hasConcept C71315377 @default.
• W4385551713 hasConcept C71924100 @default.
• W4385551713 hasConcept C77350462 @default.
• W4385551713 hasConceptScore W4385551713C126322002 @default.
• W4385551713 hasConceptScore W4385551713C134018914 @default.
• W4385551713 hasConceptScore W4385551713C151956035 @default.
• W4385551713 hasConceptScore W4385551713C156957248 @default.
• W4385551713 hasConceptScore W4385551713C2776632958 @default.
• W4385551713 hasConceptScore W4385551713C2777180221 @default.
• W4385551713 hasConceptScore W4385551713C2777195454 @default.
• W4385551713 hasConceptScore W4385551713C2779134260 @default.
• W4385551713 hasConceptScore W4385551713C2984915365 @default.
• W4385551713 hasConceptScore W4385551713C2993291352 @default.

• next