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• W4385552489 abstract "AbstractTo prepare alanine containing amphiphilic block copolymers, herein, we have polymerized methyl methacrylate (MMA) by reversible addition-fragmentation chain transfer (RAFT) polymerization and further used it as macro chain transfer agent (macroCTA) for the synthesis of PMMA-b-P(Boc-L-Ala-HEMA) (Boc-L-Ala-HEMA = tert-butyloxycarbonyl-L-alanine methacryloyloxyethyl ester) diblock copolymers. The molar masses of the macroCTA and all block copolymers as well as the dispersity (Ð) of those polymers were measured by size exclusion chromatography (SEC). The Boc-group deprotection from the block copolymers was carried out in dichloromethane by using trifluoroacetic acid to produce amphiphilic PMMA-b-P(L-Ala-HEMA), and this successful deprotection was proved by 1H NMR spectroscopy. The micellar self-assembled nature of PMMA-b-P(L-Ala-HEMA) was confirmed using a variety of techniques, including dynamic light scattering (DLS), critical aggregation concentration (CAC) determination by fluorescence spectroscopy, scanning electron microscopy (SEM), atomic force microscopy (AFM), and 1H NMR spectroscopy. The hydrophobic pyrene-tagged estrone-based natural product (NP) was encapsulated in the micellar nanostructure, proven by fluorescence spectroscopy. This encapsulating power of the corresponding polymers makes them attractive candidates as drug delivery vehicles of natural products, as well as encapsulation and delivery of other hydrophobic drug/dye molecules.Keywords: Block copolymeramino acidself-assemblypyrenenatural product Supporting informationSynthetic procedures of pyrene tagged estrone-base NP, 1H NMR, 13C NMR, ESI-MS spectra of various NP compounds, self-assembly study of DPMB3 in aqueous solution by 1H NMR spectroscopy, DLS study of DPMB1, FESEM and AFM images of the DPMB3 block copolymer, and CAC study of DPMB3 block copolymer are provided in the supporting information.AcknowledgmentsMG, PC and AB thank IISER Kolkata for their PhD fellowships. RN and AK acknowledge Department of Science & Technology (DST) – Innovation in Science Pursuit for Inspired Research (INSPIRE), Government of India, for their fellowships. PD acknowledges the Science and Engineering Research Board (SERB, Government of India, File No.: CRG/2021/000095) for partial support to carry out this work. AB thanks the SERB (STR/2020/000061) and SCP/2022/000486) for generous funding for this research.Disclosure statementNo potential conflict of interest was reported by the author(s).Additional informationFundingScience and Engineering Research Board (SERB, Government of India, File No.: CRG/2021/000095)." @default.
• W4385552489 created "2023-08-04" @default.
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• W4385552489 date "2023-08-03" @default.
• W4385552489 modified "2023-09-27" @default.
• W4385552489 title "Side-chain alanine-based block copolymer as natural product delivery system" @default.
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• W4385552489 doi "https://doi.org/10.1080/10601325.2023.2242402" @default.
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