Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385554004> ?p ?o ?g. }
- W4385554004 endingPage "600" @default.
- W4385554004 startingPage "586" @default.
- W4385554004 abstract "In the past 20 years, our understanding of the pathophysiology of depression has evolved from a focus on an imbalance of monoaminergic neurotransmitters to a multifactorial picture including an improved understanding of the role of glutamatergic excitatory and GABAergic inhibitory neurotransmission. FDA-approved treatments targeting the glutamatergic [esketamine for major depressive disorder (MDD)] and GABAergic (brexanolone for peripartum depression) systems have become available. This review focuses on the GABAA receptor (GABAAR) system as a target for novel antidepressants and discusses the mechanisms by which modulation of δ-containing GABAARs with neuroactive steroids (NASs) or of α5-containing GABAARs results in antidepressant or antidepressant-like actions and discusses clinical data on NASs. Moreover, a potential mechanism by which α5-GABAAR-positive allosteric modulators (PAMs) may improve cognitive deficits in depression is presented." @default.
- W4385554004 created "2023-08-04" @default.
- W4385554004 creator A5003007188 @default.
- W4385554004 creator A5023589964 @default.
- W4385554004 creator A5027215336 @default.
- W4385554004 creator A5036255755 @default.
- W4385554004 date "2023-09-01" @default.
- W4385554004 modified "2023-10-18" @default.
- W4385554004 title "GABAA receptors as targets for treating affective and cognitive symptoms of depression" @default.
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