Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385555096> ?p ?o ?g. }
- W4385555096 endingPage "101730" @default.
- W4385555096 startingPage "101730" @default.
- W4385555096 abstract "Cisplatin (CDDP) is an important chemotherapeutic agent, accumulation of which in kidney tissue causes nephrotoxicity and renal failure. The aim of this study was to evaluate, for the first time in the literature, the protective effect of dimethyl sulfoxide (DMSO) extract of Primula vulgaris leaf (PVE) against CDDP-induced nephrotoxicity in rats. The PVE content was characterized using liquid chromatography-mass spectrometry. Nephrotoxicity was induced with a single dose of CDDP (7.5 mg/kg). Thirty female Wistar-Albino rats were divided into five groups (control, DMSO, CDDP (7.5 mg/kg), CDDP+PVE (25 mg/kg), and CDDP+PVE (50 mg/kg)). Biochemical and histopathological analyses were then performed. Rutin, gallic acid, p-coumaric acid and protocatechuic acid were identified as major components of PVE. Total antioxidant status and glutathione (GSH) values increased significantly in the serum samples from the treatment group compared to the CDDP group, while blood urea nitrogen, creatinine, oxidative stress index, malondialdehyde (MDA), tumor necrosis factor-alpha (TNF-α), total oxidant status, and 8-hydroxy-2'-deoxyguanosine (8-OHdG) values decreased significantly. GSH levels increased significantly in the treatment group compared to the CDDP group, while TNF-α, caspase-3, 8-OHdG, MDA levels and damage scores decreased significantly. In conclusion, PVE exhibited strong protective effects through its anti-apoptotic, antioxidant, and anti-inflammatory activities against nephrotoxicity and oxidative damage caused by CDDP in rats." @default.
- W4385555096 created "2023-08-04" @default.
- W4385555096 creator A5004163768 @default.
- W4385555096 creator A5017286457 @default.
- W4385555096 creator A5055018624 @default.
- W4385555096 creator A5066890399 @default.
- W4385555096 creator A5068011450 @default.
- W4385555096 creator A5069996883 @default.
- W4385555096 creator A5075454183 @default.
- W4385555096 creator A5076029715 @default.
- W4385555096 date "2023-09-01" @default.
- W4385555096 modified "2023-10-18" @default.
- W4385555096 title "The ameliorative effect of Primula vulgaris on cisplatin-induced nephrotoxicity in rats and quantification of its phenolic components using LC-ESI-MS/MS" @default.
- W4385555096 cites W1506415669 @default.
- W4385555096 cites W1578300488 @default.
- W4385555096 cites W1812614540 @default.
- W4385555096 cites W1974694396 @default.
- W4385555096 cites W1978258343 @default.
- W4385555096 cites W1983965827 @default.
- W4385555096 cites W1999615130 @default.
- W4385555096 cites W2016318035 @default.
- W4385555096 cites W2020383780 @default.
- W4385555096 cites W2051167907 @default.
- W4385555096 cites W2053054955 @default.
- W4385555096 cites W2062145190 @default.
- W4385555096 cites W2067900674 @default.
- W4385555096 cites W2074757141 @default.
- W4385555096 cites W2112643740 @default.
- W4385555096 cites W2125056459 @default.
- W4385555096 cites W2159459465 @default.
- W4385555096 cites W2159839951 @default.
- W4385555096 cites W2185280179 @default.
- W4385555096 cites W2299154318 @default.
- W4385555096 cites W2318589452 @default.
- W4385555096 cites W2570620560 @default.
- W4385555096 cites W2592540981 @default.
- W4385555096 cites W2625790543 @default.
- W4385555096 cites W2772237312 @default.
- W4385555096 cites W2810923770 @default.
- W4385555096 cites W2902793481 @default.
- W4385555096 cites W2995043351 @default.
- W4385555096 cites W3003458955 @default.
- W4385555096 cites W3007436684 @default.
- W4385555096 cites W3026170511 @default.
- W4385555096 cites W3049306151 @default.
- W4385555096 cites W3208238374 @default.
- W4385555096 cites W3210280155 @default.
- W4385555096 cites W4200434951 @default.
- W4385555096 cites W4220668510 @default.
- W4385555096 cites W4224112487 @default.
- W4385555096 cites W4250287572 @default.
- W4385555096 cites W4290600151 @default.
- W4385555096 cites W4297100574 @default.
- W4385555096 cites W4321598783 @default.
- W4385555096 cites W3187525627 @default.
- W4385555096 doi "https://doi.org/10.1016/j.jsps.2023.101730" @default.
- W4385555096 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37583754" @default.
- W4385555096 hasPublicationYear "2023" @default.
- W4385555096 type Work @default.
- W4385555096 citedByCount "0" @default.
- W4385555096 crossrefType "journal-article" @default.
- W4385555096 hasAuthorship W4385555096A5004163768 @default.
- W4385555096 hasAuthorship W4385555096A5017286457 @default.
- W4385555096 hasAuthorship W4385555096A5055018624 @default.
- W4385555096 hasAuthorship W4385555096A5066890399 @default.
- W4385555096 hasAuthorship W4385555096A5068011450 @default.
- W4385555096 hasAuthorship W4385555096A5069996883 @default.
- W4385555096 hasAuthorship W4385555096A5075454183 @default.
- W4385555096 hasAuthorship W4385555096A5076029715 @default.
- W4385555096 hasBestOaLocation W43855550961 @default.
- W4385555096 hasConcept C126189478 @default.
- W4385555096 hasConcept C126322002 @default.
- W4385555096 hasConcept C178790620 @default.
- W4385555096 hasConcept C181199279 @default.
- W4385555096 hasConcept C185592680 @default.
- W4385555096 hasConcept C2775963812 @default.
- W4385555096 hasConcept C2776151105 @default.
- W4385555096 hasConcept C2776694085 @default.
- W4385555096 hasConcept C2778004101 @default.
- W4385555096 hasConcept C2778176769 @default.
- W4385555096 hasConcept C2778239845 @default.
- W4385555096 hasConcept C2778401633 @default.
- W4385555096 hasConcept C2780091579 @default.
- W4385555096 hasConcept C2780306776 @default.
- W4385555096 hasConcept C29730261 @default.
- W4385555096 hasConcept C538909803 @default.
- W4385555096 hasConcept C55493867 @default.
- W4385555096 hasConcept C71924100 @default.
- W4385555096 hasConcept C98274493 @default.
- W4385555096 hasConceptScore W4385555096C126189478 @default.
- W4385555096 hasConceptScore W4385555096C126322002 @default.
- W4385555096 hasConceptScore W4385555096C178790620 @default.
- W4385555096 hasConceptScore W4385555096C181199279 @default.
- W4385555096 hasConceptScore W4385555096C185592680 @default.
- W4385555096 hasConceptScore W4385555096C2775963812 @default.
- W4385555096 hasConceptScore W4385555096C2776151105 @default.
- W4385555096 hasConceptScore W4385555096C2776694085 @default.
- W4385555096 hasConceptScore W4385555096C2778004101 @default.