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- W4385555462 endingPage "2023" @default.
- W4385555462 startingPage "00400" @default.
- W4385555462 abstract "While vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) provides significant protection from coronavirus disease 2019, the protection afforded to individuals with chronic lung disease is less well established. This study seeks to understand how chronic lung disease impacts SARS-CoV-2 vaccine-elicited immunity.Deep immune phenotyping of humoral and cell-mediated responses to the SARS-CoV-2 vaccine was performed in patients with asthma, COPD and interstitial lung disease (ILD) compared to healthy controls.48% of vaccinated patients with chronic lung diseases had reduced antibody titres to the SARS-CoV-2 vaccine antigen relative to healthy controls. Vaccine antibody titres were significantly reduced among asthma (p<0.035), COPD (p<0.022) and a subset of ILD patients as early as 3-4 months after vaccination, correlating with decreased vaccine-specific memory B-cells in circulation. Vaccine-specific memory T-cells were significantly reduced in patients with asthma (CD8+ p<0.004; CD4+ p<0.023) and COPD (CD8+ p<0.008) compared to healthy controls. Impaired T-cell responsiveness was also observed in a subset of ILD patients (CD8+ 21.4%; CD4+ 42.9%). Additional heterogeneity between healthy and disease cohorts was observed among bulk and vaccine-specific follicular T-helper cells.Deep immune phenotyping of the SARS-CoV-2 vaccine response revealed the complex nature of vaccine-elicited immunity and highlights the need for more personalised vaccination schemes in patients with underlying lung conditions." @default.
- W4385555462 created "2023-08-04" @default.
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- W4385555462 date "2023-08-03" @default.
- W4385555462 modified "2023-10-18" @default.
- W4385555462 title "Vaccine-elicited B and T cell immunity to SARS-CoV-2 is impaired in chronic lung disease patients" @default.
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- W4385555462 doi "https://doi.org/10.1183/23120541.00400-2023" @default.
- W4385555462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37583809" @default.
- W4385555462 hasPublicationYear "2023" @default.