Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385555717> ?p ?o ?g. }
- W4385555717 abstract "Abstract Abundance of data on the role of inflammatory immune responses in the progression or inhibition of hepatocellular carcinoma (HCC) has failed to offer a curative immunotherapy for HCC. This is largely because of focusing on detailed specific cell types and missing the collective function of the hepatic immune system. To discover the collective immune function, we take systems immunology approach by performing high-throughput analysis of snRNAseq data collected from the liver of DIAMOND mice during the progression of nonalcoholic fatty liver disease (NAFLD) to HCC. We report that mutual signaling interactions of the hepatic immune cells in a dominant-subdominant manner, as well as their interaction with structural cells shape the immunological pattern manifesting a collective function beyond the function of the cellular constituents. Such pattern discovery approach recognized direct role of the innate immune cells in the progression of NASH and HCC. These data suggest that discovery of the immune pattern not only detects the immunological mechanism of HCC in spite of dynamic changes in immune cells during the course of disease but also offers immune modulatory interventions for the treatment of NAFLD and HCC." @default.
- W4385555717 created "2023-08-04" @default.
- W4385555717 creator A5000376105 @default.
- W4385555717 creator A5020110586 @default.
- W4385555717 creator A5024340698 @default.
- W4385555717 creator A5036945407 @default.
- W4385555717 creator A5070639714 @default.
- W4385555717 creator A5084705696 @default.
- W4385555717 creator A5089200446 @default.
- W4385555717 creator A5090286176 @default.
- W4385555717 date "2023-08-03" @default.
- W4385555717 modified "2023-10-14" @default.
- W4385555717 title "The crosstalking immune cells network creates a collective function beyond the function of each cellular constituent during the progression of hepatocellular carcinoma" @default.
- W4385555717 cites W1508172388 @default.
- W4385555717 cites W1508320954 @default.
- W4385555717 cites W1972140301 @default.
- W4385555717 cites W2000113015 @default.
- W4385555717 cites W2002999999 @default.
- W4385555717 cites W2024111238 @default.
- W4385555717 cites W2099361912 @default.
- W4385555717 cites W2102572577 @default.
- W4385555717 cites W2106549878 @default.
- W4385555717 cites W2116532751 @default.
- W4385555717 cites W2136095967 @default.
- W4385555717 cites W2146768277 @default.
- W4385555717 cites W2150659072 @default.
- W4385555717 cites W2157925255 @default.
- W4385555717 cites W2160229573 @default.
- W4385555717 cites W2179438025 @default.
- W4385555717 cites W2193699608 @default.
- W4385555717 cites W2289068089 @default.
- W4385555717 cites W2338403969 @default.
- W4385555717 cites W2415876542 @default.
- W4385555717 cites W2478438166 @default.
- W4385555717 cites W2539285510 @default.
- W4385555717 cites W2578671316 @default.
- W4385555717 cites W2609708579 @default.
- W4385555717 cites W2613498736 @default.
- W4385555717 cites W2638715417 @default.
- W4385555717 cites W2744982526 @default.
- W4385555717 cites W2776333248 @default.
- W4385555717 cites W2787586915 @default.
- W4385555717 cites W2807516380 @default.
- W4385555717 cites W2883276763 @default.
- W4385555717 cites W2899595328 @default.
- W4385555717 cites W2907514116 @default.
- W4385555717 cites W2939192576 @default.
- W4385555717 cites W2947512282 @default.
- W4385555717 cites W2969017711 @default.
- W4385555717 cites W2972236358 @default.
- W4385555717 cites W2996882089 @default.
- W4385555717 cites W3000140653 @default.
- W4385555717 cites W3004398078 @default.
- W4385555717 cites W3014902879 @default.
- W4385555717 cites W3021864086 @default.
- W4385555717 cites W3033680230 @default.
- W4385555717 cites W3035957976 @default.
- W4385555717 cites W3038974679 @default.
- W4385555717 cites W3041168967 @default.
- W4385555717 cites W3047696176 @default.
- W4385555717 cites W3125613997 @default.
- W4385555717 cites W3127571655 @default.
- W4385555717 cites W3130453114 @default.
- W4385555717 cites W3132661792 @default.
- W4385555717 cites W3138003073 @default.
- W4385555717 cites W3151027602 @default.
- W4385555717 cites W3160382869 @default.
- W4385555717 cites W3161368393 @default.
- W4385555717 cites W3163276782 @default.
- W4385555717 cites W3164692211 @default.
- W4385555717 cites W3164917474 @default.
- W4385555717 cites W3165017392 @default.
- W4385555717 cites W3170970825 @default.
- W4385555717 cites W3176314022 @default.
- W4385555717 cites W3180187472 @default.
- W4385555717 cites W3201161786 @default.
- W4385555717 cites W3205776856 @default.
- W4385555717 cites W3206948891 @default.
- W4385555717 cites W3213133368 @default.
- W4385555717 cites W3214528175 @default.
- W4385555717 cites W4205934512 @default.
- W4385555717 cites W4206238889 @default.
- W4385555717 cites W4214549882 @default.
- W4385555717 cites W4214777584 @default.
- W4385555717 cites W4283263467 @default.
- W4385555717 cites W4283325186 @default.
- W4385555717 cites W4285605783 @default.
- W4385555717 cites W4308497867 @default.
- W4385555717 cites W4308712559 @default.
- W4385555717 cites W4309531243 @default.
- W4385555717 cites W4311314369 @default.
- W4385555717 cites W4312019519 @default.
- W4385555717 cites W4313528847 @default.
- W4385555717 cites W4313555640 @default.
- W4385555717 cites W4317690326 @default.
- W4385555717 doi "https://doi.org/10.1038/s41598-023-39020-w" @default.
- W4385555717 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37537225" @default.
- W4385555717 hasPublicationYear "2023" @default.
- W4385555717 type Work @default.
- W4385555717 citedByCount "1" @default.