Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385555857> ?p ?o ?g. }
- W4385555857 endingPage "3951" @default.
- W4385555857 startingPage "3951" @default.
- W4385555857 abstract "Cervical intraepithelial neoplasia (CIN) grade 2/3 has a high spontaneous regression rate, especially among women ≤29 years of age. To reduce overtreatment, reliable prognostic biomarkers would be helpful. The main aim of this study was to analyze the negative predictive value of the methylation marker panel GynTect® for lesion regression. In this prospective, multicenter, longitudinal observational proof-of-concept study, women aged ≤29 years with histologically confirmed CIN2 (n = 24) or CIN3 (n = 36) were closely monitored without treatment for up to 24 or 12 months, respectively. The outcome was either regression, persistence, or progression of the lesion. For each patient, a single baseline sample (V0) for cytology, hrHPV detection and methylation analysis was taken. In a primary analysis, the negative predictive value (NPV) of a GynTect®-negative test result at V0 for regression was determined. We tested the null hypothesis NPV ≤ 70% against the alternative hypothesis NPV ≥ 90%. Twelve of the eighteen GynTect®-negative CIN2 patients showed regression (NPV = 67%, 90% CI 44–85%, p = 0.53). Of the 27 GynTect®-negative CIN3 lesions, 15 regressed (NPV = 56%, 90% CI 38–72%, p = 0.92). Although the majority of GynTect®-negative lesions regressed, the postulated NPV of ≥90% was not observed. Thus, the clinical relevance for an implementation of the GynTect® assay for patients undergoing watchful waiting remains questionable. Further studies with longer observation periods should be undertaken." @default.
- W4385555857 created "2023-08-04" @default.
- W4385555857 creator A5003640065 @default.
- W4385555857 creator A5007248795 @default.
- W4385555857 creator A5023079182 @default.
- W4385555857 creator A5036490646 @default.
- W4385555857 creator A5053418529 @default.
- W4385555857 creator A5053977105 @default.
- W4385555857 creator A5067427687 @default.
- W4385555857 creator A5069569309 @default.
- W4385555857 creator A5075745399 @default.
- W4385555857 creator A5076525490 @default.
- W4385555857 creator A5076959590 @default.
- W4385555857 creator A5077893389 @default.
- W4385555857 creator A5080521934 @default.
- W4385555857 creator A5081648010 @default.
- W4385555857 creator A5084519912 @default.
- W4385555857 creator A5088672440 @default.
- W4385555857 date "2023-08-03" @default.
- W4385555857 modified "2023-10-14" @default.
- W4385555857 title "Evaluation of CIN2/3 Lesion Regression in GynTect® DNA Methylation-Marker-Negative Patients in a Longitudinal Study" @default.
- W4385555857 cites W2020386919 @default.
- W4385555857 cites W2054603798 @default.
- W4385555857 cites W2120113475 @default.
- W4385555857 cites W2140566055 @default.
- W4385555857 cites W2151501050 @default.
- W4385555857 cites W2162482957 @default.
- W4385555857 cites W2243803066 @default.
- W4385555857 cites W2404579619 @default.
- W4385555857 cites W2563900151 @default.
- W4385555857 cites W2752187374 @default.
- W4385555857 cites W2765119968 @default.
- W4385555857 cites W2791080877 @default.
- W4385555857 cites W2804474317 @default.
- W4385555857 cites W2902083699 @default.
- W4385555857 cites W2944141168 @default.
- W4385555857 cites W2944382370 @default.
- W4385555857 cites W3018767052 @default.
- W4385555857 cites W3038501626 @default.
- W4385555857 cites W3095722794 @default.
- W4385555857 cites W3102683374 @default.
- W4385555857 cites W3153143002 @default.
- W4385555857 cites W316269977 @default.
- W4385555857 cites W3175932286 @default.
- W4385555857 cites W3211621799 @default.
- W4385555857 cites W4221025537 @default.
- W4385555857 cites W4224308109 @default.
- W4385555857 cites W4229068477 @default.
- W4385555857 cites W4282823078 @default.
- W4385555857 doi "https://doi.org/10.3390/cancers15153951" @default.
- W4385555857 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37568767" @default.
- W4385555857 hasPublicationYear "2023" @default.
- W4385555857 type Work @default.
- W4385555857 citedByCount "0" @default.
- W4385555857 crossrefType "journal-article" @default.
- W4385555857 hasAuthorship W4385555857A5003640065 @default.
- W4385555857 hasAuthorship W4385555857A5007248795 @default.
- W4385555857 hasAuthorship W4385555857A5023079182 @default.
- W4385555857 hasAuthorship W4385555857A5036490646 @default.
- W4385555857 hasAuthorship W4385555857A5053418529 @default.
- W4385555857 hasAuthorship W4385555857A5053977105 @default.
- W4385555857 hasAuthorship W4385555857A5067427687 @default.
- W4385555857 hasAuthorship W4385555857A5069569309 @default.
- W4385555857 hasAuthorship W4385555857A5075745399 @default.
- W4385555857 hasAuthorship W4385555857A5076525490 @default.
- W4385555857 hasAuthorship W4385555857A5076959590 @default.
- W4385555857 hasAuthorship W4385555857A5077893389 @default.
- W4385555857 hasAuthorship W4385555857A5080521934 @default.
- W4385555857 hasAuthorship W4385555857A5081648010 @default.
- W4385555857 hasAuthorship W4385555857A5084519912 @default.
- W4385555857 hasAuthorship W4385555857A5088672440 @default.
- W4385555857 hasBestOaLocation W43855558571 @default.
- W4385555857 hasConcept C121608353 @default.
- W4385555857 hasConcept C126322002 @default.
- W4385555857 hasConcept C142724271 @default.
- W4385555857 hasConcept C143998085 @default.
- W4385555857 hasConcept C18823058 @default.
- W4385555857 hasConcept C2777343196 @default.
- W4385555857 hasConcept C2778220009 @default.
- W4385555857 hasConcept C2781156865 @default.
- W4385555857 hasConcept C71924100 @default.
- W4385555857 hasConcept C90924648 @default.
- W4385555857 hasConceptScore W4385555857C121608353 @default.
- W4385555857 hasConceptScore W4385555857C126322002 @default.
- W4385555857 hasConceptScore W4385555857C142724271 @default.
- W4385555857 hasConceptScore W4385555857C143998085 @default.
- W4385555857 hasConceptScore W4385555857C18823058 @default.
- W4385555857 hasConceptScore W4385555857C2777343196 @default.
- W4385555857 hasConceptScore W4385555857C2778220009 @default.
- W4385555857 hasConceptScore W4385555857C2781156865 @default.
- W4385555857 hasConceptScore W4385555857C71924100 @default.
- W4385555857 hasConceptScore W4385555857C90924648 @default.
- W4385555857 hasIssue "15" @default.
- W4385555857 hasLocation W43855558571 @default.
- W4385555857 hasLocation W43855558572 @default.
- W4385555857 hasOpenAccess W4385555857 @default.
- W4385555857 hasPrimaryLocation W43855558571 @default.
- W4385555857 hasRelatedWork W1899355776 @default.