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- W4385556144 abstract "We use tissue susceptibility to control for iron-related off-target binding effects in 18 F-AV1451 PET and examine the impact of APOE-ε4 carrier status on striatal tau-PET signal in mild cognitive impairment. We found significant increases in tau-PET SUVR in the putamen ( p =0.01) and caudate nucleus ( p =0.046) of APOE-ε4 positive participants compared to APOE-ε4 negative participants. Controlling for striatal iron, significant correlations were seen between striatal tau-PET SUVR memory measures in the control (putamen: r =0.435; caudate: r =0.623) and APOE-ε4 positive MCI (putamen: r =0.403; caudate: r =0.648) groups with greater tau burden correlated with greater memory impairment." @default.
- W4385556144 created "2023-08-04" @default.
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- W4385556144 date "2023-08-03" @default.
- W4385556144 modified "2023-09-27" @default.
- W4385556144 title "Striatal tau deposition in mild cognitive impairment revealed by removal of iron-related off-target binding effects in 18F-AV1451 PET" @default.
- W4385556144 doi "https://doi.org/10.58530/2022/1546" @default.
- W4385556144 hasPublicationYear "2023" @default.
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