Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385556156> ?p ?o ?g. }
- W4385556156 abstract "Human glutaminyl cyclase (hQC) is drawing considerable attention and emerging as a potential druggable target for Alzheimer's disease (AD) due to its close involvement in the pathology of AD via the post-translational pyroglutamate modification of amyloid-β. A recent phase 2a study has shown promising early evidence of efficacy for AD with a competitive benzimidazole-based QC inhibitor, PQ912, which also demonstrated favorable safety profiles. This finding has sparked new hope for the treatment of AD. In this review, we briefly summarize the discovery and evolution of hQC inhibitors, with a particular interest in classic Zinc binding group (ZBG)-containing chemicals reported in recent years. Additionally, we highlight several high-potency inhibitors and discuss new trends and challenges in the development of QC inhibitors as an alternative and promising disease-modifying therapy for AD." @default.
- W4385556156 created "2023-08-04" @default.
- W4385556156 creator A5012718254 @default.
- W4385556156 creator A5030686271 @default.
- W4385556156 creator A5035701638 @default.
- W4385556156 creator A5043940449 @default.
- W4385556156 creator A5047980666 @default.
- W4385556156 creator A5061144686 @default.
- W4385556156 creator A5090695897 @default.
- W4385556156 date "2023-08-03" @default.
- W4385556156 modified "2023-10-17" @default.
- W4385556156 title "Development and evolution of human glutaminyl cyclase inhibitors (QCIs): an alternative promising approach for disease-modifying treatment of Alzheimer's disease" @default.
- W4385556156 cites W1463415903 @default.
- W4385556156 cites W1518422193 @default.
- W4385556156 cites W1552912270 @default.
- W4385556156 cites W1861771638 @default.
- W4385556156 cites W1964747897 @default.
- W4385556156 cites W1974145718 @default.
- W4385556156 cites W1980804249 @default.
- W4385556156 cites W1990632702 @default.
- W4385556156 cites W1998169335 @default.
- W4385556156 cites W1999017783 @default.
- W4385556156 cites W1999584866 @default.
- W4385556156 cites W2001073747 @default.
- W4385556156 cites W2006959956 @default.
- W4385556156 cites W2023309461 @default.
- W4385556156 cites W2024656644 @default.
- W4385556156 cites W2024917064 @default.
- W4385556156 cites W2027083068 @default.
- W4385556156 cites W2027693753 @default.
- W4385556156 cites W2028379029 @default.
- W4385556156 cites W2028711845 @default.
- W4385556156 cites W2031307279 @default.
- W4385556156 cites W2039733567 @default.
- W4385556156 cites W2039833241 @default.
- W4385556156 cites W2044646578 @default.
- W4385556156 cites W2047774085 @default.
- W4385556156 cites W2067151302 @default.
- W4385556156 cites W2070071706 @default.
- W4385556156 cites W2076742349 @default.
- W4385556156 cites W2077362716 @default.
- W4385556156 cites W2080592458 @default.
- W4385556156 cites W2083166775 @default.
- W4385556156 cites W2087577739 @default.
- W4385556156 cites W2090784101 @default.
- W4385556156 cites W2091650612 @default.
- W4385556156 cites W2092588162 @default.
- W4385556156 cites W2115715412 @default.
- W4385556156 cites W2141226820 @default.
- W4385556156 cites W2154632236 @default.
- W4385556156 cites W2192963340 @default.
- W4385556156 cites W2204663410 @default.
- W4385556156 cites W2296694142 @default.
- W4385556156 cites W2316873961 @default.
- W4385556156 cites W2329336071 @default.
- W4385556156 cites W2546826597 @default.
- W4385556156 cites W2550762885 @default.
- W4385556156 cites W2571094682 @default.
- W4385556156 cites W2589395295 @default.
- W4385556156 cites W2606113932 @default.
- W4385556156 cites W2607771058 @default.
- W4385556156 cites W2609307726 @default.
- W4385556156 cites W2610486482 @default.
- W4385556156 cites W2734651019 @default.
- W4385556156 cites W2734872819 @default.
- W4385556156 cites W2750507544 @default.
- W4385556156 cites W2790185013 @default.
- W4385556156 cites W2800581135 @default.
- W4385556156 cites W2801998557 @default.
- W4385556156 cites W2888262269 @default.
- W4385556156 cites W2891620592 @default.
- W4385556156 cites W2895816045 @default.
- W4385556156 cites W2918786033 @default.
- W4385556156 cites W2955221411 @default.
- W4385556156 cites W2966956538 @default.
- W4385556156 cites W2973838459 @default.
- W4385556156 cites W2974327745 @default.
- W4385556156 cites W2996134840 @default.
- W4385556156 cites W3005220370 @default.
- W4385556156 cites W3035927740 @default.
- W4385556156 cites W3039957777 @default.
- W4385556156 cites W3049622158 @default.
- W4385556156 cites W3113798390 @default.
- W4385556156 cites W3115914623 @default.
- W4385556156 cites W3120383433 @default.
- W4385556156 cites W3137331428 @default.
- W4385556156 cites W3137826907 @default.
- W4385556156 cites W3151538018 @default.
- W4385556156 cites W3159270015 @default.
- W4385556156 cites W3160110271 @default.
- W4385556156 cites W3185184038 @default.
- W4385556156 cites W3196637784 @default.
- W4385556156 cites W3208784158 @default.
- W4385556156 cites W3212733691 @default.
- W4385556156 cites W3216857892 @default.
- W4385556156 cites W4200292583 @default.
- W4385556156 cites W4290974116 @default.
- W4385556156 cites W4291972747 @default.
- W4385556156 cites W4304691152 @default.
- W4385556156 cites W4313650299 @default.