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- W4385562860 abstract "Neuroendocrine neoplasia (NEN) presents pertinent clinical challenges due to factors including the high rate of tumor dissemination even in low-grade disease, debate regarding optimal therapeutic strategies, and their protean clinical presentations, which may range from asymptomatic to florid endocrinopathy from hormone hypersecretion. A varied armamentarium is available for the treatment of pancreatic neuroendocrine neoplasias, including surgical, medical, and interventional radiology or nuclear medicine-based approaches. However, for some treatment modalities the quality of evidence is limited. Surgery is the only treatment option with curative attempt. Localized, biochemically confirmed, functional NEN of any size should be evaluated for surgery. Asymptomatic, nonfunctional pancreatic NEN <2<ts>cm in size may be suitable for conservative management (“watch and wait” approach). A major proportion of pancreatic NEN is disseminated to distant sites (typically the liver) at initial presentation. Multimodal treatment concepts combining surgery with nonsurgical therapeutic modalities have the potential to increase the number of patients who would be candidates for surgery and to improve long-term outcomes. Experience with biliary tract NEN is scarce, although such tumors are often amenable to surgical intervention. Here, we review the diverse presentations of and the diagnostic and therapeutic strategies for pancreatic and biliary tract NEN, discussing the indications and evidence base for each." @default.
- W4385562860 created "2023-08-04" @default.
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- W4385562860 date "2023-08-04" @default.
- W4385562860 modified "2023-10-14" @default.
- W4385562860 title "Treatment of Neuroendocrine Neoplasia of the Pancreas and Biliary Tract" @default.
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- W4385562860 doi "https://doi.org/10.1002/9781119876007.ch115" @default.
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