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- W4385563313 abstract "The cell of origin of pancreatic neuroendocrine neoplasia (PanNEN) is still the subject of debate. Data obtained using different -omics approaches as well as genetically engineered mice indicate diffuse neuroendocrine cells as the origin of PanNET and in general of neuroendocrine tumors. Lately, epigenetic signatures have indicated at least two major groups of PanNETs, one originating from β- and another from α-cells of the endocrine pancreas, with increased susceptibility for MEN1 and DAXX/ATRX mutations in α-cell tumors. Insulinomas originate from β-cells upon characteristic genetic alterations, even though transdifferentiation toward α-cells has been postulated in rare cases both in humans and in mouse models. Specific endocrine lineage transcription factors are expressed in agreement with the epigenetic group. While these data suggest an origin from adult endocrine cells, the expression of scattered progenitor markers in a subset of PanNET may indicate also a possible origin from endocrine precursor cells. In addition, cell plasticity and cell transdifferentiation complicate the delineation of a clear cell of origin in certain PanNENs. Interestingly, pancreatic neuroendocrine carcinomas seem to originate from acinar and ductal cells rather than from neuroendocrine ones." @default.
- W4385563313 created "2023-08-05" @default.
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- W4385563313 date "2023-08-04" @default.
- W4385563313 modified "2023-09-27" @default.
- W4385563313 title "What is the Origin of Pancreatic Endocrine Tumors?" @default.
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- W4385563313 doi "https://doi.org/10.1002/9781119876007.ch101" @default.
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