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- W4385564146 abstract "The molecular chaperone heat shock protein 90 (Hsp90) is essential in eukaryotes. Hsp90 chaperones proteins that are important determinants of multistep carcinogenesis. There are multiple Hsp90 isoforms including the cytosolic Hsp90α and Hsp90β as well as GRP94 located in the endoplasmic reticulum and TRAP1 in the mitochondria. The chaperone function of Hsp90 is linked to its ability to bind and hydrolyze ATP. Co-chaperones and posttranslational modifications (such as phosphorylation, SUMOylation, and ubiquitination) are important for Hsp90 stability and regulation of its ATPase activity. Both mammalian and yeast cells can be used to express and purify Hsp90 and TRAP1 and also detect post-translational modifications by immunoblotting." @default.
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- W4385564146 date "2023-01-01" @default.
- W4385564146 modified "2023-09-22" @default.
- W4385564146 title "Detecting Posttranslational Modifications of Hsp90 Isoforms" @default.
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- W4385564146 doi "https://doi.org/10.1007/978-1-0716-3342-7_11" @default.
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