Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385564324> ?p ?o ?g. }
- W4385564324 abstract "The use of bacteria and their biotic components as therapeutics has shown great potential in the treatment of diseases. Orally delivered bacteria improve patient compliance compared with injection-administered bacteria and are considered the preferred mode. However, due to the harsh gastrointestinal environment, the viability and therapeutic efficacy of orally delivered bacteria are significantly reduced in vivo. In recent years, with the rapid development of synthetic biology and nanotechnology, bacteria and biotic components have been engineered to achieve directed genetic reprogramming for construction and precise spatiotemporal control in the gastrointestinal tract, which can improve viability and therapeutic efficiency. Herein, a state-of-the-art review on the current progress of engineered bacterial systems for oral delivery is provided. The different types of bacterial and biotic components for oral administration are first summarized. The engineering strategies of these bacteria and biotic components and their treatment of diseases are next systematically summarized. Finally, the current challenges and prospects of these bacterial therapeutics are highlighted that will contribute to the development of next-generation orally delivered bacteriotherapy." @default.
- W4385564324 created "2023-08-05" @default.
- W4385564324 creator A5024427998 @default.
- W4385564324 creator A5027475579 @default.
- W4385564324 creator A5035520440 @default.
- W4385564324 creator A5037175695 @default.
- W4385564324 creator A5041977378 @default.
- W4385564324 creator A5044694464 @default.
- W4385564324 creator A5062959942 @default.
- W4385564324 date "2023-08-03" @default.
- W4385564324 modified "2023-10-15" @default.
- W4385564324 title "Advancement of Engineered Bacteria for Orally Delivered Therapeutics" @default.
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