Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385565624> ?p ?o ?g. }
- W4385565624 abstract "Nipah virus (NiV) causes a highly lethal disease in humans who present with acute respiratory or neurological signs. No vaccines against NiV have been approved to date. Here, we report on the clinical impact of a novel NiV-derived nonspreading replicon particle lacking the fusion (F) protein gene (NiVΔF) as a vaccine in three small animal models of disease. A broad antibody response was detected that included immunoglobulin G (IgG) and IgA subtypes with demonstrable Fc-mediated effector function targeting multiple viral antigens. Single-dose intranasal vaccination up to 3 days before challenge prevented clinical signs and reduced virus levels in hamsters and immunocompromised mice; decreases were seen in tissues and mucosal secretions, critically decreasing potential for virus transmission. This virus replicon particle system provides a vital tool to the field and demonstrates utility as a highly efficacious and safe vaccine candidate that can be administered parenterally or mucosally to protect against lethal Nipah disease." @default.
- W4385565624 created "2023-08-05" @default.
- W4385565624 creator A5000569375 @default.
- W4385565624 creator A5003147984 @default.
- W4385565624 creator A5004434341 @default.
- W4385565624 creator A5005452883 @default.
- W4385565624 creator A5006227397 @default.
- W4385565624 creator A5008431774 @default.
- W4385565624 creator A5014946505 @default.
- W4385565624 creator A5026125086 @default.
- W4385565624 creator A5028819455 @default.
- W4385565624 creator A5031885980 @default.
- W4385565624 creator A5034664089 @default.
- W4385565624 creator A5036692200 @default.
- W4385565624 creator A5039368253 @default.
- W4385565624 creator A5045588575 @default.
- W4385565624 creator A5055608691 @default.
- W4385565624 creator A5059702234 @default.
- W4385565624 creator A5069728846 @default.
- W4385565624 creator A5076233205 @default.
- W4385565624 creator A5086245832 @default.
- W4385565624 creator A5091196569 @default.
- W4385565624 date "2023-08-04" @default.
- W4385565624 modified "2023-10-06" @default.
- W4385565624 title "Single-dose mucosal replicon-particle vaccine protects against lethal Nipah virus infection up to 3 days after vaccination" @default.
- W4385565624 cites W1486170959 @default.
- W4385565624 cites W1551043459 @default.
- W4385565624 cites W1578049246 @default.
- W4385565624 cites W1587721581 @default.
- W4385565624 cites W1644209505 @default.
- W4385565624 cites W1963944990 @default.
- W4385565624 cites W1969126808 @default.
- W4385565624 cites W1978118805 @default.
- W4385565624 cites W1981329413 @default.
- W4385565624 cites W1986164884 @default.
- W4385565624 cites W1990512309 @default.
- W4385565624 cites W1992275074 @default.
- W4385565624 cites W2002206719 @default.
- W4385565624 cites W2005544372 @default.
- W4385565624 cites W2011977474 @default.
- W4385565624 cites W2015424616 @default.
- W4385565624 cites W2021071816 @default.
- W4385565624 cites W2021540849 @default.
- W4385565624 cites W2024814551 @default.
- W4385565624 cites W2031254719 @default.
- W4385565624 cites W2039667998 @default.
- W4385565624 cites W2041851447 @default.
- W4385565624 cites W2042499956 @default.
- W4385565624 cites W2051413287 @default.
- W4385565624 cites W2062093982 @default.
- W4385565624 cites W2070107561 @default.
- W4385565624 cites W2070921793 @default.
- W4385565624 cites W2084518431 @default.
- W4385565624 cites W2102800404 @default.
- W4385565624 cites W2105896228 @default.
- W4385565624 cites W2110564104 @default.
- W4385565624 cites W2111080041 @default.
- W4385565624 cites W2114085265 @default.
- W4385565624 cites W2133092660 @default.
- W4385565624 cites W2145364735 @default.
- W4385565624 cites W2151913784 @default.
- W4385565624 cites W2153594656 @default.
- W4385565624 cites W2159779332 @default.
- W4385565624 cites W2167713445 @default.
- W4385565624 cites W2169315144 @default.
- W4385565624 cites W2169563372 @default.
- W4385565624 cites W2171035836 @default.
- W4385565624 cites W2223009545 @default.
- W4385565624 cites W2256756668 @default.
- W4385565624 cites W2295206125 @default.
- W4385565624 cites W2301676047 @default.
- W4385565624 cites W2414639425 @default.
- W4385565624 cites W2479292935 @default.
- W4385565624 cites W2517516567 @default.
- W4385565624 cites W2519834818 @default.
- W4385565624 cites W2527841289 @default.
- W4385565624 cites W2591219968 @default.
- W4385565624 cites W2612400136 @default.
- W4385565624 cites W2783824399 @default.
- W4385565624 cites W2792262021 @default.
- W4385565624 cites W2883446746 @default.
- W4385565624 cites W2885744227 @default.
- W4385565624 cites W2898114384 @default.
- W4385565624 cites W2900051689 @default.
- W4385565624 cites W2910170730 @default.
- W4385565624 cites W2910760850 @default.
- W4385565624 cites W2912205029 @default.
- W4385565624 cites W2915623350 @default.
- W4385565624 cites W2922702530 @default.
- W4385565624 cites W2926766922 @default.
- W4385565624 cites W2937919997 @default.
- W4385565624 cites W2943881668 @default.
- W4385565624 cites W2947803240 @default.
- W4385565624 cites W2966284903 @default.
- W4385565624 cites W2975002447 @default.
- W4385565624 cites W2975454690 @default.
- W4385565624 cites W2983687434 @default.
- W4385565624 cites W2988422349 @default.
- W4385565624 cites W2989945691 @default.
- W4385565624 cites W2990311780 @default.