Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385565932> ?p ?o ?g. }
- W4385565932 endingPage "e3001852" @default.
- W4385565932 startingPage "e3001852" @default.
- W4385565932 abstract "During cortical development, human basal radial glial cells (bRGCs) are highly capable of sustained self-renewal and neurogenesis. Selective pressures on this cell type may have contributed to the evolution of the human neocortex, leading to an increase in cortical size. bRGCs have enriched expression for Forkhead Box P1 (FOXP1), a transcription factor implicated in neurodevelopmental disorders (NDDs) such as autism spectrum disorder. However, the cell type-specific roles of FOXP1 in bRGCs during cortical development remain unexplored. Here, we examine the requirement for FOXP1 gene expression regulation underlying the production of bRGCs using human brain organoids. We examine a developmental time point when FOXP1 expression is highest in the cortical progenitors, and the bRGCs, in particular, begin to actively produce neurons. With the loss of FOXP1, we show a reduction in the number of bRGCs, as well as reduced proliferation and differentiation of the remaining bRGCs, all of which lead to reduced numbers of excitatory cortical neurons over time. Using single-nuclei RNA sequencing and cell trajectory analysis, we uncover a role for FOXP1 in directing cortical progenitor proliferation and differentiation by regulating key signaling pathways related to neurogenesis and NDDs. Together, these results demonstrate that FOXP1 regulates human-specific features in early cortical development." @default.
- W4385565932 created "2023-08-05" @default.
- W4385565932 creator A5042521714 @default.
- W4385565932 creator A5043316539 @default.
- W4385565932 creator A5087082234 @default.
- W4385565932 date "2023-08-04" @default.
- W4385565932 modified "2023-09-26" @default.
- W4385565932 title "FOXP1 orchestrates neurogenesis in human cortical basal radial glial cells" @default.
- W4385565932 cites W1508717233 @default.
- W4385565932 cites W1514919670 @default.
- W4385565932 cites W1552324954 @default.
- W4385565932 cites W1580285551 @default.
- W4385565932 cites W1969353942 @default.
- W4385565932 cites W1979512659 @default.
- W4385565932 cites W1997191643 @default.
- W4385565932 cites W1997415972 @default.
- W4385565932 cites W2001473379 @default.
- W4385565932 cites W2001574193 @default.
- W4385565932 cites W2010994321 @default.
- W4385565932 cites W2016717347 @default.
- W4385565932 cites W2018286352 @default.
- W4385565932 cites W2021515035 @default.
- W4385565932 cites W2024310097 @default.
- W4385565932 cites W2040027262 @default.
- W4385565932 cites W2055562299 @default.
- W4385565932 cites W2060631152 @default.
- W4385565932 cites W2068384450 @default.
- W4385565932 cites W2085150520 @default.
- W4385565932 cites W2087962455 @default.
- W4385565932 cites W2094038606 @default.
- W4385565932 cites W2109245019 @default.
- W4385565932 cites W2120966119 @default.
- W4385565932 cites W2124649657 @default.
- W4385565932 cites W2127634492 @default.
- W4385565932 cites W2140600830 @default.
- W4385565932 cites W2146827844 @default.
- W4385565932 cites W2148665248 @default.
- W4385565932 cites W2148908764 @default.
- W4385565932 cites W2152704739 @default.
- W4385565932 cites W2166643977 @default.
- W4385565932 cites W2195294260 @default.
- W4385565932 cites W2330595735 @default.
- W4385565932 cites W2341041396 @default.
- W4385565932 cites W2411874306 @default.
- W4385565932 cites W2418103812 @default.
- W4385565932 cites W2466905356 @default.
- W4385565932 cites W2483673258 @default.
- W4385565932 cites W2507829835 @default.
- W4385565932 cites W2551021411 @default.
- W4385565932 cites W2570036960 @default.
- W4385565932 cites W2576459186 @default.
- W4385565932 cites W2604465201 @default.
- W4385565932 cites W2612886231 @default.
- W4385565932 cites W2747841296 @default.
- W4385565932 cites W2766920569 @default.
- W4385565932 cites W2768911594 @default.
- W4385565932 cites W2769636270 @default.
- W4385565932 cites W2772624269 @default.
- W4385565932 cites W2778212411 @default.
- W4385565932 cites W2781815848 @default.
- W4385565932 cites W2782326210 @default.
- W4385565932 cites W2784209987 @default.
- W4385565932 cites W2790203669 @default.
- W4385565932 cites W2792073521 @default.
- W4385565932 cites W2794480084 @default.
- W4385565932 cites W2802807976 @default.
- W4385565932 cites W2803479625 @default.
- W4385565932 cites W2809249042 @default.
- W4385565932 cites W2885012499 @default.
- W4385565932 cites W2902652978 @default.
- W4385565932 cites W2916020270 @default.
- W4385565932 cites W2924749043 @default.
- W4385565932 cites W2938910572 @default.
- W4385565932 cites W2945567049 @default.
- W4385565932 cites W2952100718 @default.
- W4385565932 cites W2955503846 @default.
- W4385565932 cites W2980995354 @default.
- W4385565932 cites W3003409042 @default.
- W4385565932 cites W3005680222 @default.
- W4385565932 cites W3009606620 @default.
- W4385565932 cites W3030250984 @default.
- W4385565932 cites W3037867273 @default.
- W4385565932 cites W3080237557 @default.
- W4385565932 cites W3082077009 @default.
- W4385565932 cites W3135166551 @default.
- W4385565932 cites W3154997353 @default.
- W4385565932 cites W3163580407 @default.
- W4385565932 cites W3165101514 @default.
- W4385565932 cites W3175922295 @default.
- W4385565932 cites W4205967011 @default.
- W4385565932 cites W4282570172 @default.
- W4385565932 cites W4298126047 @default.
- W4385565932 doi "https://doi.org/10.1371/journal.pbio.3001852" @default.
- W4385565932 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37540706" @default.
- W4385565932 hasPublicationYear "2023" @default.
- W4385565932 type Work @default.
- W4385565932 citedByCount "0" @default.
- W4385565932 crossrefType "journal-article" @default.