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- W4385567818 abstract "Macrophages are recruited to the heart and release inflammatory cytokines that interact with cardiomyocytes during myocardial ischemia reperfusion (I/R) injury. Bufalin, which was isolated from toad venom, exerts positive effects on hearts under pathological circumstances. However, the nature of the effects of bufalin on macrophages during myocardial I/R injury are still unknown. In cardiomyocytes that were cocultured with H/R-treated macrophages, ROS levels increased, and apoptosis of cardiomyocytes was triggered. H/R-treated macrophages were treated with bufalin, which inhibited the process of pyroptosis. Bufalin treatment also inhibited the release of IL-1β from H/R-treated macrophages. The apoptosis was attenuated in cardiomyocytes that were cocultured with H/R-exposed and bufalin-treated macrophages. Concomitantly, downregulation of LC3-II and accumulation of P62 were observed in H/R-treated macrophages. Bufalin was found to reverse the changes in the LC3-II and P62 levels in H/R-treated macrophages, but overexpression of p62 inhibited the anti-pyroptotic effects of bufalin. In vivo, Bufalin was shown to reverse the changes in the levels of the autophagic proteins LC3-II and p62 and the pyroptotic proteins in macrophages isolated from mice subjected to I/R. Mice that were subjected to I/R and treated with bufalin had significantly better heart function and a decreased infarct size; these effects occurred via the attenuation of the changes in the level of apoptosis of cardiomyocytes." @default.
- W4385567818 created "2023-08-05" @default.
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- W4385567818 date "2023-08-04" @default.
- W4385567818 modified "2023-09-27" @default.
- W4385567818 title "Bufalin Ameliorates Myocardial Ischemia/Reperfusion Injury through Attenuation of Macrophage Pyroptosis -Induced Cardiomyocyte Apoptosis" @default.
- W4385567818 doi "https://doi.org/10.22541/au.169117767.75751754/v1" @default.
- W4385567818 hasPublicationYear "2023" @default.
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