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• W4385568923 endingPage "108921" @default.
• W4385568923 startingPage "108921" @default.
• W4385568923 abstract "Glucocerebroside (GlcCer) is a group of compounds consisting of β-linked glucose and ceramide with various chain lengths, some of which possess anti-tumor activity and improve skin barrier function for atopic patients when administered orally. The amphiphilic GlcCer molecules are generally easy to aggregate in aqueous solution and result in low absorption in the gut, which can be improved by forming a liposome. With a recognition that a relatively large amount of GlcCer is contained in the starfish and is being discarded, we prepared a liposome consisting mainly of GlcCer (over 95%) with 100 nm in diameter. The adsorption efficiency of the liposome into cultured Caco-2 cells was investigated by live-cell imaging using fluorescently labeled liposomes. We found an immediate internalization of GlcCer-liposome on exposure without significant accumulation on the plasma membrane. The membrane fluidity was transiently affected as evidenced by fluorescence recovery after photobleaching (FRAP) experiments without no significant cellular damage, which indicates a liposome with high content of GlcCer might be useful as the carrier of dietary and/or drug molecules." @default.
• W4385568923 created "2023-08-05" @default.
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• W4385568923 date "2023-10-01" @default.
• W4385568923 modified "2023-09-27" @default.
• W4385568923 title "Cellular uptake of liposome consisting mainly of glucocerebroside from the starfish Asterias amurensis into Caco-2 cells" @default.
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• W4385568923 doi "https://doi.org/10.1016/j.carres.2023.108921" @default.
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