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- W4385569006 abstract "Alcohol misuse is the leading cause for chronic pancreatitis (CP) in industrialized nations worldwide. Alcohol misuse is the most established environmental risk factor for CP, and smoking has been recently recognized as another important risk factor. A number of pathophysiological mechanisms linking CP and alcohol misuse or smoking have been suggested. Importantly, CP develops only in a small portion of heavy drinkers. Alcohol misuse sensitizes the pancreas to injury, and additional predisposing factors including environmental and/or genetic factors are required for the development of clinical alcohol-related CP. Smoking might be such a cofactor; smoking and alcohol interact and worsen acinar cell injury and pancreatitis synergistically." @default.
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- W4385569006 date "2023-08-04" @default.
- W4385569006 modified "2023-09-27" @default.
- W4385569006 title "Alcohol and Smoking in Chronic Pancreatitis" @default.
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- W4385569006 doi "https://doi.org/10.1002/9781119876007.ch48" @default.
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