FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385575682> ?p ?o ?g. }

• W4385575682 endingPage "344" @default.
• W4385575682 startingPage "344" @default.
• W4385575682 abstract "The formation of bone in a bone defect is accomplished by osteoblasts, while the over activation of fibroblasts promotes fibrosis. However, it is not clear how the extracellular matrix stiffness of the bone-regeneration microenvironment affects the function of osteoblasts and fibroblasts. This study aim to investigate the effect of bone-regeneration microenvironment stiffness on cell adhesion, cell proliferation, cell differentiation, synthesizing matrix ability and its potential mechanisms in mechanotransduction, in pre-osteoblasts and fibroblasts. Polyacrylamide substrates mimicking the matrix stiffness of different stages of the bone-healing process (15 kPa, mimic granulation tissue; 35 kPa, mimic osteoid; 150 kPa, mimic calcified bone matrix) were prepared. Mouse pre-osteoblasts MC3T3-E1 and mouse fibroblasts NIH3T3 were plated on three types of substrates, respectively. There were significant differences in the adhesion of pre-osteoblasts and fibroblasts on different polyacrylamide substrates. Runx2 expression increased with increasing substrate stiffness in pre-osteoblasts, while no statistical differences were found in the Acta2 expression in fibroblasts on three substrates. OPN expression in pre-osteoblasts, as well as Fn1 and Col1a1 expression in fibroblasts, decreased with increasing stiffness. The difference between the cell traction force generated by pre-osteoblasts and fibroblasts on substrates was also found. Our results indicated that substrate stiffness is a potent regulator of pre-osteoblasts and fibroblasts with the ability of promoting osteogenic differentiation of pre-osteoblasts, while having no effect on myofibroblast differentiation of fibroblasts." @default.
• W4385575682 created "2023-08-05" @default.
• W4385575682 creator A5021677903 @default.
• W4385575682 creator A5027826836 @default.
• W4385575682 creator A5045927506 @default.
• W4385575682 creator A5050654748 @default.
• W4385575682 creator A5053006479 @default.
• W4385575682 creator A5066033944 @default.
• W4385575682 creator A5067483347 @default.
• W4385575682 date "2023-08-04" @default.
• W4385575682 modified "2023-09-25" @default.
• W4385575682 title "Substrate Stiffness of Bone Microenvironment Controls Functions of Pre-Osteoblasts and Fibroblasts In Vitro" @default.
• W4385575682 cites W1587510658 @default.
• W4385575682 cites W1967188390 @default.
• W4385575682 cites W1969015369 @default.
• W4385575682 cites W1980199136 @default.
• W4385575682 cites W1985716862 @default.
• W4385575682 cites W1994423139 @default.
• W4385575682 cites W1994548447 @default.
• W4385575682 cites W1996361385 @default.
• W4385575682 cites W2022746045 @default.
• W4385575682 cites W2035660111 @default.
• W4385575682 cites W2048263630 @default.
• W4385575682 cites W2050659938 @default.
• W4385575682 cites W2061731737 @default.
• W4385575682 cites W2064374431 @default.
• W4385575682 cites W2072100512 @default.
• W4385575682 cites W2087771736 @default.
• W4385575682 cites W2095301611 @default.
• W4385575682 cites W2101244168 @default.
• W4385575682 cites W2112664126 @default.
• W4385575682 cites W2119369991 @default.
• W4385575682 cites W2128520309 @default.
• W4385575682 cites W2134208433 @default.
• W4385575682 cites W2163095789 @default.
• W4385575682 cites W2397027267 @default.
• W4385575682 cites W2411612648 @default.
• W4385575682 cites W2415742027 @default.
• W4385575682 cites W2495286952 @default.
• W4385575682 cites W2546645949 @default.
• W4385575682 cites W2575862056 @default.
• W4385575682 cites W2577758672 @default.
• W4385575682 cites W2588576744 @default.
• W4385575682 cites W2737261032 @default.
• W4385575682 cites W2765939774 @default.
• W4385575682 cites W2773729171 @default.
• W4385575682 cites W2775236679 @default.
• W4385575682 cites W2782006143 @default.
• W4385575682 cites W2883162496 @default.
• W4385575682 cites W2918021199 @default.
• W4385575682 cites W2954592620 @default.
• W4385575682 cites W2990363784 @default.
• W4385575682 cites W3032045496 @default.
• W4385575682 cites W3039119266 @default.
• W4385575682 cites W3048125906 @default.
• W4385575682 cites W3083915579 @default.
• W4385575682 cites W3159439354 @default.
• W4385575682 cites W3163618693 @default.
• W4385575682 cites W4200173546 @default.
• W4385575682 cites W4200627179 @default.
• W4385575682 cites W4224290302 @default.
• W4385575682 cites W4288045074 @default.
• W4385575682 cites W4295700763 @default.
• W4385575682 cites W4313839410 @default.
• W4385575682 cites W4322493855 @default.
• W4385575682 doi "https://doi.org/10.3390/biomimetics8040344" @default.
• W4385575682 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37622949" @default.
• W4385575682 hasPublicationYear "2023" @default.
• W4385575682 type Work @default.
• W4385575682 citedByCount "0" @default.
• W4385575682 crossrefType "journal-article" @default.
• W4385575682 hasAuthorship W4385575682A5021677903 @default.
• W4385575682 hasAuthorship W4385575682A5027826836 @default.
• W4385575682 hasAuthorship W4385575682A5045927506 @default.
• W4385575682 hasAuthorship W4385575682A5050654748 @default.
• W4385575682 hasAuthorship W4385575682A5053006479 @default.
• W4385575682 hasAuthorship W4385575682A5066033944 @default.
• W4385575682 hasAuthorship W4385575682A5067483347 @default.
• W4385575682 hasBestOaLocation W43855756821 @default.
• W4385575682 hasConcept C105702510 @default.
• W4385575682 hasConcept C133605539 @default.
• W4385575682 hasConcept C134018914 @default.
• W4385575682 hasConcept C181104049 @default.
• W4385575682 hasConcept C185592680 @default.
• W4385575682 hasConcept C189165786 @default.
• W4385575682 hasConcept C198826908 @default.
• W4385575682 hasConcept C202751555 @default.
• W4385575682 hasConcept C2776363554 @default.
• W4385575682 hasConcept C2778260815 @default.
• W4385575682 hasConcept C2780381497 @default.
• W4385575682 hasConcept C2780644872 @default.
• W4385575682 hasConcept C55493867 @default.
• W4385575682 hasConcept C81880429 @default.
• W4385575682 hasConcept C86803240 @default.
• W4385575682 hasConcept C95444343 @default.
• W4385575682 hasConceptScore W4385575682C105702510 @default.
• W4385575682 hasConceptScore W4385575682C133605539 @default.
• W4385575682 hasConceptScore W4385575682C134018914 @default.

• next