Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385576255> ?p ?o ?g. }
- W4385576255 endingPage "1088" @default.
- W4385576255 startingPage "1088" @default.
- W4385576255 abstract "Profound heat stress can damage the gastrointestinal barrier, leading to microbial translocation from the gut and subsequent systemic inflammation. Despite the greater vulnerability of older people to heat wave-related morbidity and mortality, it is unknown if age modulates gastrointestinal barrier damage and inflammation during heat stress. Therefore, the aim of this study was to determine if aging impacted enterocyte damage and systemic inflammatory responses to a 3-h exposure to very hot and dry (47 °C, 15% humidity) heat with accompanying activities of daily living (intermittent activity at 3 METS). Data from 16 young (age 21 to 39 years) and 16 older (age 65 to 76 years) humans were used to address this aim. In each group, log-transformed plasma concentrations of intestinal fatty acid binding protein (I-FABPlog), interleukin-8 (IL-8log), and tissue factor (TFlog) were assessed as indices of enterocyte damage, systemic inflammation, and blood coagulation, respectively, before and after the 3-h heat exposure. In the younger cohort, I-FABPlog concentration did not increase from pre to post heat exposure (p = 0.264, d = 0.20), although it was elevated in the older group (p = 0.014, d = 0.67). The magnitude of the increase in I-FABPlog was greater in the older participants (p = 0.084, d = 0.55). Across all participants, there was no correlation between the change in core temperature and the change in IFABPlog. There was no change in IL-8log in the younger group (p = 0.193, d = 0.23) following heat exposure, but we observed a decrease in IL-8log in the older group (p = 0.047, d = 0.48). TFlog decreased in the younger group (p = 0.071, d = 0.41), but did not change in the older group (p = 0.193, d = 0.15). Our data indicate that I-FABPlog concentration (an index of enterocyte damage) is increased in older humans during a 3-h extreme heat exposure. Future studies should determine whether this marker reflects increased gastrointestinal barrier permeability in older individuals during heat exposure." @default.
- W4385576255 created "2023-08-05" @default.
- W4385576255 creator A5004530573 @default.
- W4385576255 creator A5033918661 @default.
- W4385576255 creator A5060893007 @default.
- W4385576255 creator A5070853024 @default.
- W4385576255 creator A5081520228 @default.
- W4385576255 date "2023-08-04" @default.
- W4385576255 modified "2023-09-27" @default.
- W4385576255 title "Aging Increases Enterocyte Damage during a 3-Hour Exposure to Very Hot and Dry Heat: A Preliminary Study" @default.
- W4385576255 cites W133297455 @default.
- W4385576255 cites W135836199 @default.
- W4385576255 cites W1596244991 @default.
- W4385576255 cites W1858048769 @default.
- W4385576255 cites W1947631507 @default.
- W4385576255 cites W1982786935 @default.
- W4385576255 cites W1983803767 @default.
- W4385576255 cites W1984394808 @default.
- W4385576255 cites W2001111433 @default.
- W4385576255 cites W2027847060 @default.
- W4385576255 cites W2030057679 @default.
- W4385576255 cites W2051049503 @default.
- W4385576255 cites W2051763866 @default.
- W4385576255 cites W2066035111 @default.
- W4385576255 cites W2066286996 @default.
- W4385576255 cites W2074485797 @default.
- W4385576255 cites W2076029586 @default.
- W4385576255 cites W2077979791 @default.
- W4385576255 cites W2083272138 @default.
- W4385576255 cites W2096806832 @default.
- W4385576255 cites W2102574799 @default.
- W4385576255 cites W2105045156 @default.
- W4385576255 cites W2114551066 @default.
- W4385576255 cites W2120004034 @default.
- W4385576255 cites W2129203245 @default.
- W4385576255 cites W2138328362 @default.
- W4385576255 cites W2139503434 @default.
- W4385576255 cites W2155830777 @default.
- W4385576255 cites W2158859101 @default.
- W4385576255 cites W2161754779 @default.
- W4385576255 cites W2166537607 @default.
- W4385576255 cites W2216159787 @default.
- W4385576255 cites W2607434574 @default.
- W4385576255 cites W2752307627 @default.
- W4385576255 cites W2765043188 @default.
- W4385576255 cites W2884592288 @default.
- W4385576255 cites W2911772760 @default.
- W4385576255 cites W2957935821 @default.
- W4385576255 cites W3007982518 @default.
- W4385576255 cites W3024420385 @default.
- W4385576255 cites W3036023440 @default.
- W4385576255 cites W3039171595 @default.
- W4385576255 cites W3124125535 @default.
- W4385576255 cites W3184231620 @default.
- W4385576255 cites W357316772 @default.
- W4385576255 cites W3924815 @default.
- W4385576255 cites W4205124095 @default.
- W4385576255 cites W4211183003 @default.
- W4385576255 cites W4224239338 @default.
- W4385576255 cites W4225863267 @default.
- W4385576255 cites W4283794184 @default.
- W4385576255 cites W4383314111 @default.
- W4385576255 cites W49138001 @default.
- W4385576255 cites W74438234 @default.
- W4385576255 doi "https://doi.org/10.3390/biology12081088" @default.
- W4385576255 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37626974" @default.
- W4385576255 hasPublicationYear "2023" @default.
- W4385576255 type Work @default.
- W4385576255 citedByCount "0" @default.
- W4385576255 crossrefType "journal-article" @default.
- W4385576255 hasAuthorship W4385576255A5004530573 @default.
- W4385576255 hasAuthorship W4385576255A5033918661 @default.
- W4385576255 hasAuthorship W4385576255A5060893007 @default.
- W4385576255 hasAuthorship W4385576255A5070853024 @default.
- W4385576255 hasAuthorship W4385576255A5081520228 @default.
- W4385576255 hasBestOaLocation W43855762551 @default.
- W4385576255 hasConcept C126322002 @default.
- W4385576255 hasConcept C134018914 @default.
- W4385576255 hasConcept C203014093 @default.
- W4385576255 hasConcept C2776252253 @default.
- W4385576255 hasConcept C2776914184 @default.
- W4385576255 hasConcept C2777882243 @default.
- W4385576255 hasConcept C2779604457 @default.
- W4385576255 hasConcept C42407357 @default.
- W4385576255 hasConcept C71924100 @default.
- W4385576255 hasConcept C86803240 @default.
- W4385576255 hasConceptScore W4385576255C126322002 @default.
- W4385576255 hasConceptScore W4385576255C134018914 @default.
- W4385576255 hasConceptScore W4385576255C203014093 @default.
- W4385576255 hasConceptScore W4385576255C2776252253 @default.
- W4385576255 hasConceptScore W4385576255C2776914184 @default.
- W4385576255 hasConceptScore W4385576255C2777882243 @default.
- W4385576255 hasConceptScore W4385576255C2779604457 @default.
- W4385576255 hasConceptScore W4385576255C42407357 @default.
- W4385576255 hasConceptScore W4385576255C71924100 @default.
- W4385576255 hasConceptScore W4385576255C86803240 @default.
- W4385576255 hasIssue "8" @default.
- W4385576255 hasLocation W43855762551 @default.