FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385576300> ?p ?o ?g. }

• W4385576300 abstract "Abstract Background Insulin is commonly used in type 2 diabetes mellitus (T2DM) to achieve glycemic control. However, recent evidence showed that insulin use is associated with poor outcomes in the context of heart failure (HF). Since heart failure with reduced ejection fraction (HFrEF) accounts for approximately 50% of cases in the general HF population, we aimed to evaluate the effect of insulin treatment on left ventricular (LV) remodeling and contractility abnormalities in a HFrEF cohort and assess whether insulin was a predictor of adverse outcomes in this entity. Methods A total of 377 HFrEF patients who underwent cardiac MRI were included and divided according to diabetes status and the need for insulin treatment. LV structural and functional indices, as well as systolic strains, were measured. The determinants of impaired myocardial strains were assessed using linear regression analysis. The associated endpoints were determined using a multivariable Cox proportional hazards model. Results T2DM patients on insulin displayed a higher indexed LV end-diastolic volume and LV mass than those with T2DM not on insulin or those without T2DM, despite similar LV ejection fractions, accompanied by a higher three-dimensional spherical index (P < 0.01). Worse longitudinal and circumferential peak systolic strain was shown to occur in T2DM patients on insulin (P < 0.01). Insulin treatment was independently associated with impaired magnitudes of systolic strain. The median follow-up duration was 32.4 months (IQR, 15.6–43.2 months). Insulin treatment remained consistently associated with poor outcomes after adjustment for established confounders, with an adjusted hazard ratio of 3.11; (95% CI, 1.45–6.87; P = 0.009) in the overall cohort and 2.16 (95% CI, 1.08–4.59; P = 0.030) in the diabetes cohort. Conclusions Insulin may further lead to adverse LV remodeling and contractile dysfunction in the context of HFrEF with T2DM. Considerable care should be taken when treating HFrEF patients with insulin." @default.
• W4385576300 created "2023-08-05" @default.
• W4385576300 creator A5005303316 @default.
• W4385576300 creator A5016319758 @default.
• W4385576300 creator A5020100539 @default.
• W4385576300 creator A5021905069 @default.
• W4385576300 creator A5028913617 @default.
• W4385576300 creator A5029079971 @default.
• W4385576300 creator A5037133029 @default.
• W4385576300 creator A5048575289 @default.
• W4385576300 creator A5049971270 @default.
• W4385576300 creator A5053192318 @default.
• W4385576300 creator A5057796157 @default.
• W4385576300 creator A5088757206 @default.
• W4385576300 date "2023-08-04" @default.
• W4385576300 modified "2023-10-17" @default.
• W4385576300 title "Association of insulin use with LV remodeling and clinical outcomes in diabetic patients with heart failure and reduced ejection fraction: assessed by cardiac MRI" @default.
• W4385576300 cites W1975663485 @default.
• W4385576300 cites W2101732802 @default.
• W4385576300 cites W2468379348 @default.
• W4385576300 cites W2540516921 @default.
• W4385576300 cites W2625031949 @default.
• W4385576300 cites W2710470494 @default.
• W4385576300 cites W2761212002 @default.
• W4385576300 cites W2780874826 @default.
• W4385576300 cites W2792867832 @default.
• W4385576300 cites W2914358481 @default.
• W4385576300 cites W2917743074 @default.
• W4385576300 cites W2953451576 @default.
• W4385576300 cites W2968633786 @default.
• W4385576300 cites W2980621767 @default.
• W4385576300 cites W2997790100 @default.
• W4385576300 cites W3047208451 @default.
• W4385576300 cites W3088773047 @default.
• W4385576300 cites W3151303043 @default.
• W4385576300 cites W3184399299 @default.
• W4385576300 cites W3193598686 @default.
• W4385576300 cites W3197347343 @default.
• W4385576300 cites W3199801809 @default.
• W4385576300 cites W3208377810 @default.
• W4385576300 cites W4213425264 @default.
• W4385576300 cites W4229041853 @default.
• W4385576300 cites W4283158940 @default.
• W4385576300 doi "https://doi.org/10.1186/s12933-023-01944-y" @default.
• W4385576300 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37542280" @default.
• W4385576300 hasPublicationYear "2023" @default.
• W4385576300 type Work @default.
• W4385576300 citedByCount "0" @default.
• W4385576300 crossrefType "journal-article" @default.
• W4385576300 hasAuthorship W4385576300A5005303316 @default.
• W4385576300 hasAuthorship W4385576300A5016319758 @default.
• W4385576300 hasAuthorship W4385576300A5020100539 @default.
• W4385576300 hasAuthorship W4385576300A5021905069 @default.
• W4385576300 hasAuthorship W4385576300A5028913617 @default.
• W4385576300 hasAuthorship W4385576300A5029079971 @default.
• W4385576300 hasAuthorship W4385576300A5037133029 @default.
• W4385576300 hasAuthorship W4385576300A5048575289 @default.
• W4385576300 hasAuthorship W4385576300A5049971270 @default.
• W4385576300 hasAuthorship W4385576300A5053192318 @default.
• W4385576300 hasAuthorship W4385576300A5057796157 @default.
• W4385576300 hasAuthorship W4385576300A5088757206 @default.
• W4385576300 hasBestOaLocation W43855763001 @default.
• W4385576300 hasConcept C126322002 @default.
• W4385576300 hasConcept C134018914 @default.
• W4385576300 hasConcept C151730666 @default.
• W4385576300 hasConcept C164705383 @default.
• W4385576300 hasConcept C207103383 @default.
• W4385576300 hasConcept C2778198053 @default.
• W4385576300 hasConcept C2779306644 @default.
• W4385576300 hasConcept C2779343474 @default.
• W4385576300 hasConcept C2908647359 @default.
• W4385576300 hasConcept C2910068830 @default.
• W4385576300 hasConcept C44249647 @default.
• W4385576300 hasConcept C50382708 @default.
• W4385576300 hasConcept C555175668 @default.
• W4385576300 hasConcept C555293320 @default.
• W4385576300 hasConcept C71924100 @default.
• W4385576300 hasConcept C78085059 @default.
• W4385576300 hasConcept C86803240 @default.
• W4385576300 hasConcept C99454951 @default.
• W4385576300 hasConceptScore W4385576300C126322002 @default.
• W4385576300 hasConceptScore W4385576300C134018914 @default.
• W4385576300 hasConceptScore W4385576300C151730666 @default.
• W4385576300 hasConceptScore W4385576300C164705383 @default.
• W4385576300 hasConceptScore W4385576300C207103383 @default.
• W4385576300 hasConceptScore W4385576300C2778198053 @default.
• W4385576300 hasConceptScore W4385576300C2779306644 @default.
• W4385576300 hasConceptScore W4385576300C2779343474 @default.
• W4385576300 hasConceptScore W4385576300C2908647359 @default.
• W4385576300 hasConceptScore W4385576300C2910068830 @default.
• W4385576300 hasConceptScore W4385576300C44249647 @default.
• W4385576300 hasConceptScore W4385576300C50382708 @default.
• W4385576300 hasConceptScore W4385576300C555175668 @default.
• W4385576300 hasConceptScore W4385576300C555293320 @default.
• W4385576300 hasConceptScore W4385576300C71924100 @default.
• W4385576300 hasConceptScore W4385576300C78085059 @default.
• W4385576300 hasConceptScore W4385576300C86803240 @default.
• W4385576300 hasConceptScore W4385576300C99454951 @default.
• W4385576300 hasFunder F4320321001 @default.
• W4385576300 hasIssue "1" @default.

• next