Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385576337> ?p ?o ?g. }
- W4385576337 endingPage "101337" @default.
- W4385576337 startingPage "101337" @default.
- W4385576337 abstract "Respiratory syncytial virus (RSV) and human metapneumovirus (hMPV) continue to be a global burden to infants, the elderly, and immunocompromised individuals. In the past ten years, there has been substantial progress in the development of new vaccine candidates and therapies against these viruses. These advancements were guided by the structural elucidation of the major surface glycoproteins for these viruses, the fusion (F) protein and attachment (G) protein. The identification of immunodominant epitopes on the RSV F and hMPV F proteins has expanded current knowledge on antibody-mediated immune responses, which has led to new approaches for vaccine and therapeutic development through the stabilization of pre-fusion constructs of the F protein and pre-fusion-specific monoclonal antibodies with high potency and efficacy. In this review, we describe structural characteristics of known antigenic sites on the RSV and hMPV proteins, their influence on the immune response, and current progress in vaccine and therapeutic development." @default.
- W4385576337 created "2023-08-05" @default.
- W4385576337 creator A5033222756 @default.
- W4385576337 creator A5042643001 @default.
- W4385576337 date "2023-08-01" @default.
- W4385576337 modified "2023-09-27" @default.
- W4385576337 title "Structural basis for respiratory syncytial virus and human metapneumovirus neutralization" @default.
- W4385576337 cites W150036197 @default.
- W4385576337 cites W1829554927 @default.
- W4385576337 cites W1962254654 @default.
- W4385576337 cites W1978340605 @default.
- W4385576337 cites W1983849915 @default.
- W4385576337 cites W1984286626 @default.
- W4385576337 cites W1986189079 @default.
- W4385576337 cites W1989215346 @default.
- W4385576337 cites W2000128679 @default.
- W4385576337 cites W2004663239 @default.
- W4385576337 cites W2016019047 @default.
- W4385576337 cites W2031276907 @default.
- W4385576337 cites W2034880469 @default.
- W4385576337 cites W2040299410 @default.
- W4385576337 cites W2043056303 @default.
- W4385576337 cites W2083613414 @default.
- W4385576337 cites W2083637922 @default.
- W4385576337 cites W2087228984 @default.
- W4385576337 cites W2094048920 @default.
- W4385576337 cites W2094770210 @default.
- W4385576337 cites W2096654319 @default.
- W4385576337 cites W2096922886 @default.
- W4385576337 cites W2102553812 @default.
- W4385576337 cites W2106930670 @default.
- W4385576337 cites W2123184297 @default.
- W4385576337 cites W2126114330 @default.
- W4385576337 cites W2137778587 @default.
- W4385576337 cites W2139442175 @default.
- W4385576337 cites W2139907403 @default.
- W4385576337 cites W2140242346 @default.
- W4385576337 cites W2142544822 @default.
- W4385576337 cites W2147917005 @default.
- W4385576337 cites W2151727763 @default.
- W4385576337 cites W2161617554 @default.
- W4385576337 cites W2164992622 @default.
- W4385576337 cites W2170881661 @default.
- W4385576337 cites W2171602693 @default.
- W4385576337 cites W2177875401 @default.
- W4385576337 cites W2270869679 @default.
- W4385576337 cites W2404438359 @default.
- W4385576337 cites W2414229300 @default.
- W4385576337 cites W2525417966 @default.
- W4385576337 cites W2562747978 @default.
- W4385576337 cites W2580797815 @default.
- W4385576337 cites W2582217477 @default.
- W4385576337 cites W2605757983 @default.
- W4385576337 cites W2606016017 @default.
- W4385576337 cites W2767506818 @default.
- W4385576337 cites W2771831788 @default.
- W4385576337 cites W2784885284 @default.
- W4385576337 cites W2787934792 @default.
- W4385576337 cites W2790804090 @default.
- W4385576337 cites W2896780995 @default.
- W4385576337 cites W2901328586 @default.
- W4385576337 cites W2911813404 @default.
- W4385576337 cites W2919205146 @default.
- W4385576337 cites W2921646015 @default.
- W4385576337 cites W2932380022 @default.
- W4385576337 cites W2938362339 @default.
- W4385576337 cites W2939729367 @default.
- W4385576337 cites W2958885912 @default.
- W4385576337 cites W2964965456 @default.
- W4385576337 cites W2968758140 @default.
- W4385576337 cites W2972594574 @default.
- W4385576337 cites W2981899643 @default.
- W4385576337 cites W2995687198 @default.
- W4385576337 cites W3017122459 @default.
- W4385576337 cites W3024848554 @default.
- W4385576337 cites W3046024889 @default.
- W4385576337 cites W3084204945 @default.
- W4385576337 cites W3092643437 @default.
- W4385576337 cites W3154936721 @default.
- W4385576337 cites W3170717671 @default.
- W4385576337 cites W3190510554 @default.
- W4385576337 cites W3195138227 @default.
- W4385576337 cites W3211514846 @default.
- W4385576337 cites W4200280195 @default.
- W4385576337 cites W4205493674 @default.
- W4385576337 cites W4220994000 @default.
- W4385576337 cites W4229441544 @default.
- W4385576337 cites W4229454852 @default.
- W4385576337 cites W4235140553 @default.
- W4385576337 cites W4255884628 @default.
- W4385576337 cites W4282597920 @default.
- W4385576337 cites W4282835226 @default.
- W4385576337 cites W4288687353 @default.
- W4385576337 cites W4290612370 @default.
- W4385576337 cites W4295540545 @default.
- W4385576337 cites W4307227444 @default.
- W4385576337 cites W4311747511 @default.
- W4385576337 cites W4319759244 @default.