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- W4385580708 abstract "Abstract Small extracellular vesicles (sEV) in TNBC patients’ plasma promote T cell dysfunction and tumor progression. Here we show that tumor cell-derived exosomes (TEX) carrying surface PDL-1, PD-1, Fas, FasL, TRAIL, CTLA-4 and TGF-β1 induce apoptosis of CD8 + T and CD4 + T cells but spare B and NK cells. Inhibitors blocking TEX-induce receptor/ligand signals and TEX pretreatments with proteinase K or heat fail to prevent T cell apoptosis. Cytochalasin D, Dynosore or Pit Stop 2, partly inhibit TEX uptake but do not prevent T cell apoptosis. TEX entry into T cells induces cytochrome C and Smac release from mitochondria and caspase-3 and PARP cleavage in the cytosol. Expression of survival proteins is reduced in T cells undergoing apoptosis. Independently of external death receptor signaling, TEX entry into T cells induces mitochondrial stress, initiating relentless intrinsic apoptosis, which is responsible for death of activated T cells in the tumor-bearing hosts. The abundance of TEX in cancer plasma represents a danger for adoptively transferred T cells, limiting their therapeutic potential." @default.
- W4385580708 created "2023-08-05" @default.
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- W4385580708 date "2023-08-04" @default.
- W4385580708 modified "2023-10-18" @default.
- W4385580708 title "Small EV in plasma of triple negative breast cancer patients induce intrinsic apoptosis in activated T cells" @default.
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- W4385580708 doi "https://doi.org/10.1038/s42003-023-05169-3" @default.
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