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- W4385582386 abstract "Abstract Biofilms are cooperative bacterial communities, in which diffusible signal-mediated quorum sensing coordinates the activities of member cells. However, limited diffusion in extracellular polymeric substance (EPS)-filled biofilms suggests existence of another intercellular signaling mechanism that is more adapted to the biofilm environment. Here, I demonstrate that the yfjA operon of Bacillus subtilis encodes one such signaling mechanism. The yfjA operon was induced by the two-component system DegSU, which controls biofilm development. Deleting the yfjA operon resulted in increased expression of DegSU-regulated genes under nutrient-rich conditions, hastening the onset of sporulation in biofilms. The yfjA operon encoded the type VII secretion system effector toxin YFJ in addition to its related proteins. YFJ toxin-mediated intercellular competition required EPS components which promote close cell-cell association, suggesting that the contact-dependent YFJ toxin system functions specifically in biofilms. The YFJ toxin also functioned as an intercellular signal that controlled the activity of DegSU. I propose that the YFJ toxin system is a biofilm-specific intercellular signaling mechanism that controls cell fate in biofilms in response to nutrient conditions and population size." @default.
- W4385582386 created "2023-08-05" @default.
- W4385582386 creator A5080530083 @default.
- W4385582386 date "2023-08-03" @default.
- W4385582386 modified "2023-09-27" @default.
- W4385582386 title "A type VII secretion system toxin functioning as a biofilm-specific intercellular signal in<i>Bacillus subtilis</i>" @default.
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- W4385582386 doi "https://doi.org/10.1101/2023.08.02.551746" @default.
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