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- W4385583384 abstract "Abstract Candida albicans is a commensal of the human microbiota that can form biofilms on implanted medical devices. These biofilms are tolerant to antifungals and to the host immune system. To identify novel genes modulating C. albicans biofilm formation, we performed a large-scale screen with 2454 C. albicans doxycycline-dependent overexpression strains and identified 16 genes whose overexpression significantly hampered biofilm formation. Among those, overexpression of the ZCF15 and ZCF26 paralogs that encode transcription factors and have orthologs only in biofilm-forming species of the Candida clade, caused impaired biofilm formation both in vitro and in vivo . Interestingly, overexpression of ZCF15 specifically impeded biofilm formation without any defect in hyphal growth. Transcript profiling, transcription factor binding, and phenotypic microarray analyses conducted upon overexpression of ZCF15 and ZCF26 demonstrated their direct role in reprogramming cellular metabolism by regulating glycolytic cycle and tricarboxylic acid cycle genes. Taken together, this study has identified a new set of biofilm regulators, including ZCF15 and ZCF26, that appear to control biofilm development through their specific role in metabolic remodeling." @default.
- W4385583384 created "2023-08-05" @default.
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- W4385583384 date "2023-08-03" @default.
- W4385583384 modified "2023-10-02" @default.
- W4385583384 title "Metabolic reprogramming during<i>Candida albicans</i>planktonic-biofilm transition is modulated by the<i>ZCF15</i>and<i>ZCF26</i>paralogs" @default.
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- W4385583384 doi "https://doi.org/10.1101/2023.08.03.551767" @default.
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