Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385584345> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W4385584345 endingPage "iii32" @default.
- W4385584345 startingPage "iii32" @default.
- W4385584345 abstract "Abstract BACKGROUND Glioblastoma (GBM), is the most common primary brain tumor. GBM contains a small subpopulation of glioma stem cells (GSCs) that are implicated in tumor recurrence and treatment resistance and therefore represent important therapeutic targets. Recent clinical studies suggest propofol impacts subsequent tumor response to treatments and patient prognosis. The effects of propofol on patient derived GSCs alone and in combination with radiation and temozolomide, (TMZ) have not been reported. Objectives: The molecular mechanisms underlying propofol’s anti-tumor effects on GSCs and its effect on cellular communication with microglia was studied. Using GSC spheroids, differentiated glioma and tumor cells on a microfluid chip, effects of propofol alone and together with radiation and TMZ on the self-renewal and stemness of GSCs, their mesenchymal transit and the proliferation and apoptosis of differentiated glioma cells was analyzed. Using transwell plates, the effects of propofol on the cross-talk of GSCs with human microglia cells was examined. RESULTS Propofol exerted a dose-dependent inhibitory effect on the self-renewal, expression of mesenchymal markers and migration of GSCs and sensitized them to both temozolomide (TMZ) and radiation. At higher concentrations propofol induced a large degree of cell death as demonstrated using microfluid chip. Propofol increased the expression of the lncRNA BDNF-AS, which acts as a tumor suppressor in GBM and silencing of this lncRNA partially abrogated propofol’s anti-tumor effects. Propofol also inhibited the pro-tumorigenic GSC-microglia cross talk via extracellular vesicles (EVs) and delivery of BDNF-AS. CONCLUSIONS Propofol exerted anti-tumor effects on GSCs and differentiated glioma cells by inhibiting cell renewal, proliferation, and mesenchymal transition and by inducing cell death at higher concentration. Propofol also sensitized GSCs to radiation and TMZ. Propofol, which is widely used in GBM surgeries, should be further explored as a potential repurposed drug during resection and an effective adjunct to radiation and TMZ." @default.
- W4385584345 created "2023-08-05" @default.
- W4385584345 creator A5003243219 @default.
- W4385584345 creator A5011112075 @default.
- W4385584345 creator A5014077327 @default.
- W4385584345 creator A5023857986 @default.
- W4385584345 creator A5041474889 @default.
- W4385584345 creator A5058625264 @default.
- W4385584345 creator A5071979955 @default.
- W4385584345 creator A5072824630 @default.
- W4385584345 creator A5075735447 @default.
- W4385584345 creator A5081610776 @default.
- W4385584345 creator A5082731794 @default.
- W4385584345 creator A5084103283 @default.
- W4385584345 date "2023-08-01" @default.
- W4385584345 modified "2023-10-18" @default.
- W4385584345 title "SYST-24 PROPOFOL EXERTS ANTI-TUMOR EFFECTS IN GLIOMA AND THE TUMOR MICROENVIRONMENT VIA NON-CODING RNAS AND SECRETED EXOSOMES" @default.
- W4385584345 doi "https://doi.org/10.1093/noajnl/vdad070.126" @default.
- W4385584345 hasPublicationYear "2023" @default.
- W4385584345 type Work @default.
- W4385584345 citedByCount "0" @default.
- W4385584345 crossrefType "journal-article" @default.
- W4385584345 hasAuthorship W4385584345A5003243219 @default.
- W4385584345 hasAuthorship W4385584345A5011112075 @default.
- W4385584345 hasAuthorship W4385584345A5014077327 @default.
- W4385584345 hasAuthorship W4385584345A5023857986 @default.
- W4385584345 hasAuthorship W4385584345A5041474889 @default.
- W4385584345 hasAuthorship W4385584345A5058625264 @default.
- W4385584345 hasAuthorship W4385584345A5071979955 @default.
- W4385584345 hasAuthorship W4385584345A5072824630 @default.
- W4385584345 hasAuthorship W4385584345A5075735447 @default.
- W4385584345 hasAuthorship W4385584345A5081610776 @default.
- W4385584345 hasAuthorship W4385584345A5082731794 @default.
- W4385584345 hasAuthorship W4385584345A5084103283 @default.
- W4385584345 hasBestOaLocation W43855843451 @default.
- W4385584345 hasConcept C104317684 @default.
- W4385584345 hasConcept C119056186 @default.
- W4385584345 hasConcept C142724271 @default.
- W4385584345 hasConcept C190283241 @default.
- W4385584345 hasConcept C198826908 @default.
- W4385584345 hasConcept C203014093 @default.
- W4385584345 hasConcept C2776277131 @default.
- W4385584345 hasConcept C2776914184 @default.
- W4385584345 hasConcept C2777389519 @default.
- W4385584345 hasConcept C2778227246 @default.
- W4385584345 hasConcept C2779130545 @default.
- W4385584345 hasConcept C2779830541 @default.
- W4385584345 hasConcept C502942594 @default.
- W4385584345 hasConcept C55493867 @default.
- W4385584345 hasConcept C71924100 @default.
- W4385584345 hasConcept C86803240 @default.
- W4385584345 hasConcept C98274493 @default.
- W4385584345 hasConceptScore W4385584345C104317684 @default.
- W4385584345 hasConceptScore W4385584345C119056186 @default.
- W4385584345 hasConceptScore W4385584345C142724271 @default.
- W4385584345 hasConceptScore W4385584345C190283241 @default.
- W4385584345 hasConceptScore W4385584345C198826908 @default.
- W4385584345 hasConceptScore W4385584345C203014093 @default.
- W4385584345 hasConceptScore W4385584345C2776277131 @default.
- W4385584345 hasConceptScore W4385584345C2776914184 @default.
- W4385584345 hasConceptScore W4385584345C2777389519 @default.
- W4385584345 hasConceptScore W4385584345C2778227246 @default.
- W4385584345 hasConceptScore W4385584345C2779130545 @default.
- W4385584345 hasConceptScore W4385584345C2779830541 @default.
- W4385584345 hasConceptScore W4385584345C502942594 @default.
- W4385584345 hasConceptScore W4385584345C55493867 @default.
- W4385584345 hasConceptScore W4385584345C71924100 @default.
- W4385584345 hasConceptScore W4385584345C86803240 @default.
- W4385584345 hasConceptScore W4385584345C98274493 @default.
- W4385584345 hasIssue "Supplement_3" @default.
- W4385584345 hasLocation W43855843451 @default.
- W4385584345 hasOpenAccess W4385584345 @default.
- W4385584345 hasPrimaryLocation W43855843451 @default.
- W4385584345 hasRelatedWork W2040830156 @default.
- W4385584345 hasRelatedWork W2058548052 @default.
- W4385584345 hasRelatedWork W2745825872 @default.
- W4385584345 hasRelatedWork W3009730465 @default.
- W4385584345 hasRelatedWork W3010013908 @default.
- W4385584345 hasRelatedWork W3013154413 @default.
- W4385584345 hasRelatedWork W3015696786 @default.
- W4385584345 hasRelatedWork W3042466763 @default.
- W4385584345 hasRelatedWork W4220865729 @default.
- W4385584345 hasRelatedWork W4293364348 @default.
- W4385584345 hasVolume "5" @default.
- W4385584345 isParatext "false" @default.
- W4385584345 isRetracted "false" @default.
- W4385584345 workType "article" @default.