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- W4385587881 abstract "Enhancers are essential cis-acting regulatory elements that determine cell identity and tumor progression. Enhancer function is dependent on the physical interaction between the enhancer and its target promoter inside its local chromatin environment. Enhancer reprogramming is an important mechanism in cancer pathogenesis and can be driven by both cis and trans factors. Super enhancers are acquired at oncogenes in numerous cancer types and represent potential targets for cancer treatment. BET and CDK inhibitors act through mechanisms of enhancer function and have shown promising results in therapy for various types of cancer. Genome editing is another way to reprogram enhancers in cancer treatment. The relationship between enhancers and cancer has been revised by several authors in the past few years, which mainly focuses on the mechanisms by which enhancers can impact cancer. Here, we emphasize SE's role in cancer pathogenesis and the new therapies involving epigenetic regulators (BETi and CDKi). We suggest that understanding mechanisms of activity would aid clinical success for these anti-cancer agents." @default.
- W4385587881 created "2023-08-05" @default.
- W4385587881 creator A5045149570 @default.
- W4385587881 creator A5050537896 @default.
- W4385587881 creator A5065190234 @default.
- W4385587881 creator A5070892221 @default.
- W4385587881 date "2023-01-01" @default.
- W4385587881 modified "2023-09-26" @default.
- W4385587881 title "Enhancer in cancer pathogenesis and treatment" @default.
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