Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385588185> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W4385588185 abstract "Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers with increasing incidence. Even if progress have been made, the five-year overall survival remains lower than 10%. There is a desperate need in therapeutic improvements. In the last two decades, new in-vitro models have been developed and improved, including tridimensional-culture spheroids and organoids. However, animal studies remain mandatory in the upscaling before clinical studies. Orthotopic and syngeneic grafting is a robust model to test a drug efficiency in a tumor and its microenvironment.We described a method for orthotopic and syngeneic graft of KRAS mutated, p53 wildtype, 8305 cells in a C57BL/6J mouse model.With this microsurgical method, 30 mice were grafted, 24 by a junior and six by a senior, resulting in 95,8 and 100% of (partial and total) successful tumoral implantation, respectively. Twenty mice underwent ultrasound follow-up. It was an efficient method for the tumoral growth evaluation. At day 16 after grafting, 85% of the tumors were detectable by ultrasound, and at day 22 all tumors were detected.The presented method appears to be a robust and reliable method for pre-clinical studies. A junior master student can provide positive results using this technique, which can be improved with training." @default.
- W4385588185 created "2023-08-05" @default.
- W4385588185 creator A5008077511 @default.
- W4385588185 creator A5024798692 @default.
- W4385588185 creator A5034714383 @default.
- W4385588185 creator A5035411007 @default.
- W4385588185 creator A5049731648 @default.
- W4385588185 creator A5052139084 @default.
- W4385588185 creator A5075544061 @default.
- W4385588185 creator A5078518284 @default.
- W4385588185 date "2023-01-01" @default.
- W4385588185 modified "2023-10-18" @default.
- W4385588185 title "Pancreatic cancer orthotopic graft in a murine model" @default.
- W4385588185 cites W1968812902 @default.
- W4385588185 cites W1980833988 @default.
- W4385588185 cites W2010916968 @default.
- W4385588185 cites W2016459836 @default.
- W4385588185 cites W2107780185 @default.
- W4385588185 cites W2110598677 @default.
- W4385588185 cites W2123407979 @default.
- W4385588185 cites W2151253787 @default.
- W4385588185 cites W2165480504 @default.
- W4385588185 cites W2795248085 @default.
- W4385588185 cites W2808529706 @default.
- W4385588185 cites W2884691005 @default.
- W4385588185 cites W2886525607 @default.
- W4385588185 cites W2905888775 @default.
- W4385588185 cites W2947548345 @default.
- W4385588185 cites W2967450000 @default.
- W4385588185 cites W3029024305 @default.
- W4385588185 cites W3157377634 @default.
- W4385588185 cites W3200665948 @default.
- W4385588185 cites W3215659102 @default.
- W4385588185 cites W4211208840 @default.
- W4385588185 cites W4295901435 @default.
- W4385588185 doi "https://doi.org/10.1590/acb382823" @default.
- W4385588185 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37556720" @default.
- W4385588185 hasPublicationYear "2023" @default.
- W4385588185 type Work @default.
- W4385588185 citedByCount "0" @default.
- W4385588185 crossrefType "journal-article" @default.
- W4385588185 hasAuthorship W4385588185A5008077511 @default.
- W4385588185 hasAuthorship W4385588185A5024798692 @default.
- W4385588185 hasAuthorship W4385588185A5034714383 @default.
- W4385588185 hasAuthorship W4385588185A5035411007 @default.
- W4385588185 hasAuthorship W4385588185A5049731648 @default.
- W4385588185 hasAuthorship W4385588185A5052139084 @default.
- W4385588185 hasAuthorship W4385588185A5075544061 @default.
- W4385588185 hasAuthorship W4385588185A5078518284 @default.
- W4385588185 hasBestOaLocation W43855881851 @default.
- W4385588185 hasConcept C121608353 @default.
- W4385588185 hasConcept C126322002 @default.
- W4385588185 hasConcept C142724271 @default.
- W4385588185 hasConcept C143998085 @default.
- W4385588185 hasConcept C2778117688 @default.
- W4385588185 hasConcept C2780210213 @default.
- W4385588185 hasConcept C2781187634 @default.
- W4385588185 hasConcept C2992026798 @default.
- W4385588185 hasConcept C502942594 @default.
- W4385588185 hasConcept C526805850 @default.
- W4385588185 hasConcept C71924100 @default.
- W4385588185 hasConceptScore W4385588185C121608353 @default.
- W4385588185 hasConceptScore W4385588185C126322002 @default.
- W4385588185 hasConceptScore W4385588185C142724271 @default.
- W4385588185 hasConceptScore W4385588185C143998085 @default.
- W4385588185 hasConceptScore W4385588185C2778117688 @default.
- W4385588185 hasConceptScore W4385588185C2780210213 @default.
- W4385588185 hasConceptScore W4385588185C2781187634 @default.
- W4385588185 hasConceptScore W4385588185C2992026798 @default.
- W4385588185 hasConceptScore W4385588185C502942594 @default.
- W4385588185 hasConceptScore W4385588185C526805850 @default.
- W4385588185 hasConceptScore W4385588185C71924100 @default.
- W4385588185 hasLocation W43855881851 @default.
- W4385588185 hasLocation W43855881852 @default.
- W4385588185 hasOpenAccess W4385588185 @default.
- W4385588185 hasPrimaryLocation W43855881851 @default.
- W4385588185 hasRelatedWork W1964699883 @default.
- W4385588185 hasRelatedWork W2112087504 @default.
- W4385588185 hasRelatedWork W2325171952 @default.
- W4385588185 hasRelatedWork W2337441440 @default.
- W4385588185 hasRelatedWork W2620319885 @default.
- W4385588185 hasRelatedWork W2799708148 @default.
- W4385588185 hasRelatedWork W2961842639 @default.
- W4385588185 hasRelatedWork W2983108327 @default.
- W4385588185 hasRelatedWork W4367553346 @default.
- W4385588185 hasRelatedWork W4386293350 @default.
- W4385588185 hasVolume "38" @default.
- W4385588185 isParatext "false" @default.
- W4385588185 isRetracted "false" @default.
- W4385588185 workType "article" @default.