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• W4385597703 endingPage "108920" @default.
• W4385597703 startingPage "108920" @default.
• W4385597703 abstract "Cinnamic acid-containing sugar compounds such as phenylethanoid glycosides are widely present in nature and display various biological activities. In this work, the synthesis of trans-cinnamic acid containing phenylethanoid glycosides was achieved via palladium-catalyzed cross-coupling reactions between glycosyl acrylic esters and aryldiazonium salts. A wide range of functionalized aryldiazonium salts were successfully coupled with 6-O- and 4-O-acrylic esters of glucose under optimized conditions. The reactions proceeded at room temperature in the absence of additives and base. The desired products were obtained in good to excellent yields. Selected compounds from the library were screened for anti-Alzheimer activity, while compound 16 displayed significant inhibitory activities against butyrylcholinesterase (BChE) and acetylcholinesterase (AChE) enzymes." @default.
• W4385597703 created "2023-08-05" @default.
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• W4385597703 date "2023-10-01" @default.
• W4385597703 modified "2023-10-12" @default.
• W4385597703 title "Synthesis of phenylethanoid glycosides from acrylic esters of glucose and aryldiazonium salts via palladium-catalyzed cross-coupling reactions and evaluation of their anti-Alzheimer activity" @default.
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• W4385597703 doi "https://doi.org/10.1016/j.carres.2023.108920" @default.
• W4385597703 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37586143" @default.
• W4385597703 hasPublicationYear "2023" @default.
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