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• W4385597772 endingPage "110832" @default.
• W4385597772 startingPage "110832" @default.
• W4385597772 abstract "RNA helicase DHX33 has been shown to be aberrantly expressed in various human cancers, however, its role in tumorigenesis remains incompletely understood. In this report, we uncovered that a family of DNA architecture proteins, HMGBs, can be regulated by DHX33 in cancer cells but not in normal cells. Specifically, DHX33 knockdown caused the downregulation of HMGBs at the levels of both gene transcription and protein expression. Notably, in RAS driven lung tumorigenesis, nuclear HMGBs proteins can be induced via DHX33. When DHX33 was knocked out, HMGBs overexpression was debilitated. Mechanistically, DHX33 was found to bind to the promoters of HMGB family genes and regulated their transcription through demethylation on gene promoters. Our study reveals a novel mechanism for DHX33 to promote tumorigenesis and highlights its therapeutic value in human cancers." @default.
• W4385597772 created "2023-08-05" @default.
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• W4385597772 date "2023-10-01" @default.
• W4385597772 modified "2023-10-17" @default.
• W4385597772 title "RNA helicase DHX33 regulates HMGB family genes in human cancer cells" @default.
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• W4385597772 doi "https://doi.org/10.1016/j.cellsig.2023.110832" @default.
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• W4385597772 hasPublicationYear "2023" @default.
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