FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385602009> ?p ?o ?g. }

• W4385602009 endingPage "38308" @default.
• W4385602009 startingPage "38294" @default.
• W4385602009 abstract "Loading hyaluronidase (Hyal) in a nanocarrier is a potent strategy to degrade the tumor extracellular matrix for tumor deep penetration and enhanced tumor therapy. Herein, a pH-sensitive biomimicking nanosystem with high Hyal loading, effective tumor targeting, and controllable release is constructed. Specifically, cationic mesoporous silica nanoparticles (CMSNs) with large pores 13.52 nm in diameter were synthesized in a one-pot manner by adding N-[3-trimethoxysilylpropyl]-N,N,N-trimethylammonium to a reversed microemulsion reaction system. The Hyal loading rate was as high as 19.47% owing to matched pore size and the cationic surface charge. Subsequently, a pH-sensitive biomimetic hybrid membrane (pHH) composed of pH-sensitive liposome (pHL), red blood cell membrane, and pancreatic cancer cell membrane was camouflaged on the pHL-coated and doxorubicin/Hyal-loaded CMSNs (shortened as DHCM). The DHCM@pHL@pHH is stable at neutral pH while it releases the payloads smoothly in the tumor acidic microenvironment. Consequently, it can escape from macrophage clearance, be specifically taken up by pancreatic cancer cells, and efficiently accumulate at the tumor site. More importantly, it can penetrate deeply in pancreatic tumors with a tumor growth inhibition ratio of 80.46%. The nanosystem is biocompatible and has potential for clinical transformation, and the nanocarrier is promisingly applicable as a platform for encapsulation of various macromolecules for smart and tumor-targeted delivery." @default.
• W4385602009 created "2023-08-05" @default.
• W4385602009 creator A5038084670 @default.
• W4385602009 creator A5041846457 @default.
• W4385602009 creator A5047894137 @default.
• W4385602009 creator A5078594799 @default.
• W4385602009 creator A5091344867 @default.
• W4385602009 creator A5091859146 @default.
• W4385602009 date "2023-08-05" @default.
• W4385602009 modified "2023-10-11" @default.
• W4385602009 title "pH-Sensitive Biomimetic Nanosystem Based on Large-Pore Mesoporous Silica Nanoparticles with High Hyaluronidase Loading for Tumor Deep Penetration" @default.
• W4385602009 cites W1532604253 @default.
• W4385602009 cites W156191869 @default.
• W4385602009 cites W1976041621 @default.
• W4385602009 cites W1993606172 @default.
• W4385602009 cites W2040087569 @default.
• W4385602009 cites W2040650724 @default.
• W4385602009 cites W2051349300 @default.
• W4385602009 cites W2057718146 @default.
• W4385602009 cites W2066469419 @default.
• W4385602009 cites W2079048547 @default.
• W4385602009 cites W2090837623 @default.
• W4385602009 cites W2139172602 @default.
• W4385602009 cites W2165031969 @default.
• W4385602009 cites W2272767623 @default.
• W4385602009 cites W2296997375 @default.
• W4385602009 cites W2322861634 @default.
• W4385602009 cites W2594354610 @default.
• W4385602009 cites W2795161016 @default.
• W4385602009 cites W2904772704 @default.
• W4385602009 cites W2944251418 @default.
• W4385602009 cites W2949066002 @default.
• W4385602009 cites W2970926098 @default.
• W4385602009 cites W2980258067 @default.
• W4385602009 cites W2989983390 @default.
• W4385602009 cites W2991006009 @default.
• W4385602009 cites W2994794750 @default.
• W4385602009 cites W3016405601 @default.
• W4385602009 cites W3040831456 @default.
• W4385602009 cites W3116163911 @default.
• W4385602009 cites W3213908732 @default.
• W4385602009 cites W4307026415 @default.
• W4385602009 cites W4320712417 @default.
• W4385602009 doi "https://doi.org/10.1021/acsami.3c06909" @default.
• W4385602009 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37542453" @default.
• W4385602009 hasPublicationYear "2023" @default.
• W4385602009 type Work @default.
• W4385602009 citedByCount "0" @default.
• W4385602009 crossrefType "journal-article" @default.
• W4385602009 hasAuthorship W4385602009A5038084670 @default.
• W4385602009 hasAuthorship W4385602009A5041846457 @default.
• W4385602009 hasAuthorship W4385602009A5047894137 @default.
• W4385602009 hasAuthorship W4385602009A5078594799 @default.
• W4385602009 hasAuthorship W4385602009A5091344867 @default.
• W4385602009 hasAuthorship W4385602009A5091859146 @default.
• W4385602009 hasConcept C121608353 @default.
• W4385602009 hasConcept C12554922 @default.
• W4385602009 hasConcept C126322002 @default.
• W4385602009 hasConcept C127413603 @default.
• W4385602009 hasConcept C155672457 @default.
• W4385602009 hasConcept C15920480 @default.
• W4385602009 hasConcept C159985019 @default.
• W4385602009 hasConcept C161790260 @default.
• W4385602009 hasConcept C171250308 @default.
• W4385602009 hasConcept C181199279 @default.
• W4385602009 hasConcept C18150654 @default.
• W4385602009 hasConcept C183882617 @default.
• W4385602009 hasConcept C185592680 @default.
• W4385602009 hasConcept C188027245 @default.
• W4385602009 hasConcept C192562407 @default.
• W4385602009 hasConcept C2777496208 @default.
• W4385602009 hasConcept C2780375986 @default.
• W4385602009 hasConcept C41625074 @default.
• W4385602009 hasConcept C42360764 @default.
• W4385602009 hasConcept C42475967 @default.
• W4385602009 hasConcept C521977710 @default.
• W4385602009 hasConcept C55493867 @default.
• W4385602009 hasConcept C71924100 @default.
• W4385602009 hasConcept C80107235 @default.
• W4385602009 hasConcept C82776694 @default.
• W4385602009 hasConcept C86803240 @default.
• W4385602009 hasConcept C9132879 @default.
• W4385602009 hasConcept C96232424 @default.
• W4385602009 hasConceptScore W4385602009C121608353 @default.
• W4385602009 hasConceptScore W4385602009C12554922 @default.
• W4385602009 hasConceptScore W4385602009C126322002 @default.
• W4385602009 hasConceptScore W4385602009C127413603 @default.
• W4385602009 hasConceptScore W4385602009C155672457 @default.
• W4385602009 hasConceptScore W4385602009C15920480 @default.
• W4385602009 hasConceptScore W4385602009C159985019 @default.
• W4385602009 hasConceptScore W4385602009C161790260 @default.
• W4385602009 hasConceptScore W4385602009C171250308 @default.
• W4385602009 hasConceptScore W4385602009C181199279 @default.
• W4385602009 hasConceptScore W4385602009C18150654 @default.
• W4385602009 hasConceptScore W4385602009C183882617 @default.
• W4385602009 hasConceptScore W4385602009C185592680 @default.
• W4385602009 hasConceptScore W4385602009C188027245 @default.
• W4385602009 hasConceptScore W4385602009C192562407 @default.

• next