Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385604171> ?p ?o ?g. }
- W4385604171 abstract "Abstract The development of new therapies is hampered by the lack of predictive, and patient-relevant in vitro models. Organ-on-chip (OOC) technologies can potentially recreate physiological features and hold great promise for tissue and disease modeling. However, the non-standardized design of these chips and perfusion control systems has been a barrier to quantitative high-throughput screening (HTS). Here we present a scalable OOC microfluidic platform for applied kinetic in vitro assays (AKITA) that is applicable for high, medium, and low throughput. Its standard 96-well plate and 384-well plate layouts ensure compatibility with existing laboratory workflows and high-throughput data collection and analysis tools. The AKITA plate is optimized for the modeling of vascularized biological barriers, primarily the blood-brain barrier, skin, and lung, with precise flow control on a custom rocker. The integration of trans-epithelial electrical resistance (TEER) sensors allows rapid and repeated monitoring of barrier integrity over long time periods. Together with automated confocal imaging and compound permeability testing analyses, we demonstrate the flexibility of the AKITA platform for establishing human-relevant models for preclinical drug and precision medicine’s efficacy, toxicity, and permeability under physiological conditions." @default.
- W4385604171 created "2023-08-05" @default.
- W4385604171 creator A5012241317 @default.
- W4385604171 creator A5014436096 @default.
- W4385604171 creator A5023432538 @default.
- W4385604171 creator A5023851960 @default.
- W4385604171 creator A5025051967 @default.
- W4385604171 creator A5026237119 @default.
- W4385604171 creator A5049217863 @default.
- W4385604171 creator A5058308244 @default.
- W4385604171 creator A5061805930 @default.
- W4385604171 creator A5086951358 @default.
- W4385604171 creator A5092600872 @default.
- W4385604171 creator A5092600873 @default.
- W4385604171 creator A5092600874 @default.
- W4385604171 creator A5092600875 @default.
- W4385604171 creator A5050634374 @default.
- W4385604171 date "2023-08-05" @default.
- W4385604171 modified "2023-09-27" @default.
- W4385604171 title "Highly scalable and standardized organ-on-chip platform with TEER for biological barrier modeling" @default.
- W4385604171 cites W1154526730 @default.
- W4385604171 cites W1595796602 @default.
- W4385604171 cites W1844839288 @default.
- W4385604171 cites W1967105697 @default.
- W4385604171 cites W1976537943 @default.
- W4385604171 cites W1989224577 @default.
- W4385604171 cites W2004863952 @default.
- W4385604171 cites W2010874323 @default.
- W4385604171 cites W2012867417 @default.
- W4385604171 cites W2013099472 @default.
- W4385604171 cites W2028279608 @default.
- W4385604171 cites W2052214665 @default.
- W4385604171 cites W2058811019 @default.
- W4385604171 cites W2059944938 @default.
- W4385604171 cites W2065812641 @default.
- W4385604171 cites W2067189227 @default.
- W4385604171 cites W2074073922 @default.
- W4385604171 cites W2076922024 @default.
- W4385604171 cites W2084871881 @default.
- W4385604171 cites W2116809022 @default.
- W4385604171 cites W2152239270 @default.
- W4385604171 cites W2154555351 @default.
- W4385604171 cites W2190027095 @default.
- W4385604171 cites W2256963343 @default.
- W4385604171 cites W2306735846 @default.
- W4385604171 cites W2501779583 @default.
- W4385604171 cites W2511446702 @default.
- W4385604171 cites W2521188938 @default.
- W4385604171 cites W2591803479 @default.
- W4385604171 cites W2601277777 @default.
- W4385604171 cites W2768964688 @default.
- W4385604171 cites W2782509008 @default.
- W4385604171 cites W2783569768 @default.
- W4385604171 cites W2789751902 @default.
- W4385604171 cites W2789816271 @default.
- W4385604171 cites W2793367223 @default.
- W4385604171 cites W2911032805 @default.
- W4385604171 cites W2971766156 @default.
- W4385604171 cites W2995961474 @default.
- W4385604171 cites W3003181931 @default.
- W4385604171 cites W3012783513 @default.
- W4385604171 cites W3032099014 @default.
- W4385604171 cites W3099056121 @default.
- W4385604171 cites W3111418538 @default.
- W4385604171 cites W3144782134 @default.
- W4385604171 cites W3168667198 @default.
- W4385604171 cites W3180880508 @default.
- W4385604171 cites W3186170869 @default.
- W4385604171 cites W4220909482 @default.
- W4385604171 cites W4366828055 @default.
- W4385604171 doi "https://doi.org/10.1101/2023.08.02.551612" @default.
- W4385604171 hasPublicationYear "2023" @default.
- W4385604171 type Work @default.
- W4385604171 citedByCount "0" @default.
- W4385604171 crossrefType "posted-content" @default.
- W4385604171 hasAuthorship W4385604171A5012241317 @default.
- W4385604171 hasAuthorship W4385604171A5014436096 @default.
- W4385604171 hasAuthorship W4385604171A5023432538 @default.
- W4385604171 hasAuthorship W4385604171A5023851960 @default.
- W4385604171 hasAuthorship W4385604171A5025051967 @default.
- W4385604171 hasAuthorship W4385604171A5026237119 @default.
- W4385604171 hasAuthorship W4385604171A5049217863 @default.
- W4385604171 hasAuthorship W4385604171A5050634374 @default.
- W4385604171 hasAuthorship W4385604171A5058308244 @default.
- W4385604171 hasAuthorship W4385604171A5061805930 @default.
- W4385604171 hasAuthorship W4385604171A5086951358 @default.
- W4385604171 hasAuthorship W4385604171A5092600872 @default.
- W4385604171 hasAuthorship W4385604171A5092600873 @default.
- W4385604171 hasAuthorship W4385604171A5092600874 @default.
- W4385604171 hasAuthorship W4385604171A5092600875 @default.
- W4385604171 hasBestOaLocation W43856041711 @default.
- W4385604171 hasConcept C105795698 @default.
- W4385604171 hasConcept C127413603 @default.
- W4385604171 hasConcept C136229726 @default.
- W4385604171 hasConcept C165932988 @default.
- W4385604171 hasConcept C171250308 @default.
- W4385604171 hasConcept C177212765 @default.
- W4385604171 hasConcept C192562407 @default.
- W4385604171 hasConcept C2780598303 @default.
- W4385604171 hasConcept C33923547 @default.