Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385604454> ?p ?o ?g. }
- W4385604454 endingPage "19" @default.
- W4385604454 startingPage "1" @default.
- W4385604454 abstract "Immunoregulation is crucial to septic shock (SS) but has not been clearly explained. Our aim was to explore potential biomarkers for SS by pathway and transcriptional analyses of immune-related genes to improve early detection. GSE57065 and GSE95233 microarray data were used to screen differentially expressed genes (DEGs) in SS. Gene Ontology and KEGG (Kyoto Encyclopedia of Genes and Genomes) pathway enrichment analyses of DEGs were performed, and correlations between immune cell and pathway enrichment scores were analyzed. The predictive value of candidate genes was evaluated by receiver operating characteristic (ROC) curves. GSE66099, GSE4607, and GSE13904 datasets were used for external validation. Blood samples from six patients and six controls were collected for validation by qRT-PCR and western blotting. In total, 550 DEGs in SS were identified; these genes were involved in the immune response, inflammation, and infection. Immune-related pathways and levels of infiltration of CD4 + TCM, CD8 + T cells, and preadipocytes differed between SS cases and controls. Seventeen genes were identified as potential biomarkers of SS (areas under ROC curves >0.9). The downregulation of CD8A, CD247, CD3G, LCK, and HLA-DRA in SS was experimentally confirmed. We identified several immune-related biomarkers in SS that may improve early identification of disease risk." @default.
- W4385604454 created "2023-08-05" @default.
- W4385604454 creator A5013093589 @default.
- W4385604454 creator A5025897494 @default.
- W4385604454 creator A5026246996 @default.
- W4385604454 creator A5035009834 @default.
- W4385604454 creator A5037283045 @default.
- W4385604454 creator A5055435596 @default.
- W4385604454 date "2023-08-05" @default.
- W4385604454 modified "2023-09-26" @default.
- W4385604454 title "Identification of Potential Biomarkers of Septic Shock Based on Pathway and Transcriptome Analyses of Immune-Related Genes" @default.
- W4385604454 cites W122167022 @default.
- W4385604454 cites W154781782 @default.
- W4385604454 cites W1990148803 @default.
- W4385604454 cites W2010457001 @default.
- W4385604454 cites W2035618305 @default.
- W4385604454 cites W2036461169 @default.
- W4385604454 cites W2041620385 @default.
- W4385604454 cites W2047998870 @default.
- W4385604454 cites W2053701857 @default.
- W4385604454 cites W2059100079 @default.
- W4385604454 cites W2060441151 @default.
- W4385604454 cites W2064586782 @default.
- W4385604454 cites W2101748726 @default.
- W4385604454 cites W2103017472 @default.
- W4385604454 cites W2105924489 @default.
- W4385604454 cites W2127506019 @default.
- W4385604454 cites W2154362705 @default.
- W4385604454 cites W2158217645 @default.
- W4385604454 cites W2159482845 @default.
- W4385604454 cites W2159675211 @default.
- W4385604454 cites W2159707944 @default.
- W4385604454 cites W2164990391 @default.
- W4385604454 cites W2332078202 @default.
- W4385604454 cites W2523170972 @default.
- W4385604454 cites W2738380241 @default.
- W4385604454 cites W2743622884 @default.
- W4385604454 cites W2770395397 @default.
- W4385604454 cites W2786533447 @default.
- W4385604454 cites W2914941679 @default.
- W4385604454 cites W2952001873 @default.
- W4385604454 cites W2966322347 @default.
- W4385604454 cites W2966695488 @default.
- W4385604454 cites W2971128094 @default.
- W4385604454 cites W2972579304 @default.
- W4385604454 cites W2996598715 @default.
- W4385604454 cites W3004433158 @default.
- W4385604454 cites W3025110062 @default.
- W4385604454 cites W3026003031 @default.
- W4385604454 cites W3033116902 @default.
- W4385604454 cites W3163764050 @default.
- W4385604454 cites W4206016373 @default.
- W4385604454 cites W4212971931 @default.
- W4385604454 cites W4220720705 @default.
- W4385604454 cites W4281999765 @default.
- W4385604454 cites W4283773109 @default.
- W4385604454 cites W4294216483 @default.
- W4385604454 cites W4311297742 @default.
- W4385604454 doi "https://doi.org/10.1155/2023/9991613" @default.
- W4385604454 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37575977" @default.
- W4385604454 hasPublicationYear "2023" @default.
- W4385604454 type Work @default.
- W4385604454 citedByCount "0" @default.
- W4385604454 crossrefType "journal-article" @default.
- W4385604454 hasAuthorship W4385604454A5013093589 @default.
- W4385604454 hasAuthorship W4385604454A5025897494 @default.
- W4385604454 hasAuthorship W4385604454A5026246996 @default.
- W4385604454 hasAuthorship W4385604454A5035009834 @default.
- W4385604454 hasAuthorship W4385604454A5037283045 @default.
- W4385604454 hasAuthorship W4385604454A5055435596 @default.
- W4385604454 hasBestOaLocation W43856044541 @default.
- W4385604454 hasConcept C104317684 @default.
- W4385604454 hasConcept C127561419 @default.
- W4385604454 hasConcept C150194340 @default.
- W4385604454 hasConcept C152724338 @default.
- W4385604454 hasConcept C162317418 @default.
- W4385604454 hasConcept C167672396 @default.
- W4385604454 hasConcept C186836561 @default.
- W4385604454 hasConcept C203014093 @default.
- W4385604454 hasConcept C2779018089 @default.
- W4385604454 hasConcept C54355233 @default.
- W4385604454 hasConcept C70721500 @default.
- W4385604454 hasConcept C8415881 @default.
- W4385604454 hasConcept C86803240 @default.
- W4385604454 hasConcept C8891405 @default.
- W4385604454 hasConceptScore W4385604454C104317684 @default.
- W4385604454 hasConceptScore W4385604454C127561419 @default.
- W4385604454 hasConceptScore W4385604454C150194340 @default.
- W4385604454 hasConceptScore W4385604454C152724338 @default.
- W4385604454 hasConceptScore W4385604454C162317418 @default.
- W4385604454 hasConceptScore W4385604454C167672396 @default.
- W4385604454 hasConceptScore W4385604454C186836561 @default.
- W4385604454 hasConceptScore W4385604454C203014093 @default.
- W4385604454 hasConceptScore W4385604454C2779018089 @default.
- W4385604454 hasConceptScore W4385604454C54355233 @default.
- W4385604454 hasConceptScore W4385604454C70721500 @default.
- W4385604454 hasConceptScore W4385604454C8415881 @default.
- W4385604454 hasConceptScore W4385604454C86803240 @default.