FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385605208> ?p ?o ?g. }

• W4385605208 endingPage "101732" @default.
• W4385605208 startingPage "101732" @default.
• W4385605208 abstract "Epilepsy is a chronic neurological disorder marked by recurrent seizures, significantly affecting the population in Saudi Arabia across all age demographics. The global prevalence of active epilepsy is around 6.38/1,000 persons and in the Arabian region, the median prevalence of active epilepsy is 4.4/1,000 persons. However, over 75% of individuals are untreated. Consequently, the development of therapeutic strategies with increased efficacy and safety profiles is essential to improve the survival rate among epilepsy patients. The current study integrates network pharmacology along with Bioinformatics approaches to explore the potential molecular mechanisms of local flora of Saudi Arabia including Solanum incanum, Abrus precatorius, Withania somnifera, and Azadirachta indica in epilepsy treatment. In the preliminary phase, data related to the bioactive components of the local plants and the associated target genes of both these plants and epilepsy were gathered from scientific literature and open-source databases. This data was then analyzed to identify common targets between the plants and ovarian cancer. Based on these common targets, a protein-protein interaction (PPI) network was constructed utilizing the STRING database, which was subsequently incorporated into the Cytoscape software for identification of hub genes based on their degree of connectivity. Lastly, an interplay network depicting the associations between the compounds and the overlapping genes was formulated via Cytoscape, to study the potential network pharmacology implications of these active compounds in relation to ovarian cancer. Following that, a compound-target protein-pathway network was constructed which uncovered that namely abrectorin, genistin, (+)-catechin, precatorine, (+)-ascorbic acid, licoflavanone, skrofulein, stigmasterone, 5,7-Dihydroxy-4'-methoxy-8,3'-di-C-prenylflavanone could potentially be used as antagonists for the therapeutic management of epilepsy by targeting TNF and TP53 proteins. Furthermore, the implementation of molecular docking reinforces the binding affinity of the compound, indicating a robust stability of the forecasted compounds at the docked site. This research lays both a theoretical and experimental groundwork for more profound investigations and establishes a practical method for the strategic employment of active compounds in the development of anti-epileptic therapeutics." @default.
• W4385605208 created "2023-08-06" @default.
• W4385605208 creator A5013681019 @default.
• W4385605208 creator A5078940974 @default.
• W4385605208 creator A5084674191 @default.
• W4385605208 creator A5091526230 @default.
• W4385605208 date "2023-09-01" @default.
• W4385605208 modified "2023-10-05" @default.
• W4385605208 title "Exploring the multi-gene regulatory molecular mechanism of Saudi Arabian flora against epilepsy based on data mining, network pharmacology and docking analysis" @default.
• W4385605208 cites W140380069 @default.
• W4385605208 cites W1875368412 @default.
• W4385605208 cites W1887624773 @default.
• W4385605208 cites W1970581535 @default.
• W4385605208 cites W2061871005 @default.
• W4385605208 cites W2064791107 @default.
• W4385605208 cites W2067670322 @default.
• W4385605208 cites W2079733845 @default.
• W4385605208 cites W2087175872 @default.
• W4385605208 cites W2098214115 @default.
• W4385605208 cites W2103912979 @default.
• W4385605208 cites W2122683221 @default.
• W4385605208 cites W2123500593 @default.
• W4385605208 cites W2123634240 @default.
• W4385605208 cites W2131347449 @default.
• W4385605208 cites W2139942857 @default.
• W4385605208 cites W2159675211 @default.
• W4385605208 cites W2168938595 @default.
• W4385605208 cites W2181069053 @default.
• W4385605208 cites W2277704060 @default.
• W4385605208 cites W2474747771 @default.
• W4385605208 cites W2593436234 @default.
• W4385605208 cites W2605775938 @default.
• W4385605208 cites W2720897370 @default.
• W4385605208 cites W2734356283 @default.
• W4385605208 cites W2767891136 @default.
• W4385605208 cites W2772385663 @default.
• W4385605208 cites W2787229753 @default.
• W4385605208 cites W2792944991 @default.
• W4385605208 cites W2801088198 @default.
• W4385605208 cites W2804721038 @default.
• W4385605208 cites W2911761011 @default.
• W4385605208 cites W2949305189 @default.
• W4385605208 cites W2966449460 @default.
• W4385605208 cites W2983166786 @default.
• W4385605208 cites W2995459561 @default.
• W4385605208 cites W2999145612 @default.
• W4385605208 cites W3012042308 @default.
• W4385605208 cites W3023885322 @default.
• W4385605208 cites W3035511928 @default.
• W4385605208 cites W3158814319 @default.
• W4385605208 cites W3183343568 @default.
• W4385605208 cites W4220953887 @default.
• W4385605208 cites W4225373799 @default.
• W4385605208 cites W4237095724 @default.
• W4385605208 cites W4255677297 @default.
• W4385605208 cites W4309510370 @default.
• W4385605208 cites W4362731391 @default.
• W4385605208 cites W4377195289 @default.
• W4385605208 doi "https://doi.org/10.1016/j.jsps.2023.101732" @default.
• W4385605208 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37638220" @default.
• W4385605208 hasPublicationYear "2023" @default.
• W4385605208 type Work @default.
• W4385605208 citedByCount "0" @default.
• W4385605208 crossrefType "journal-article" @default.
• W4385605208 hasAuthorship W4385605208A5013681019 @default.
• W4385605208 hasAuthorship W4385605208A5078940974 @default.
• W4385605208 hasAuthorship W4385605208A5084674191 @default.
• W4385605208 hasAuthorship W4385605208A5091526230 @default.
• W4385605208 hasBestOaLocation W43856052081 @default.
• W4385605208 hasConcept C104317684 @default.
• W4385605208 hasConcept C118552586 @default.
• W4385605208 hasConcept C142724271 @default.
• W4385605208 hasConcept C155261790 @default.
• W4385605208 hasConcept C204787440 @default.
• W4385605208 hasConcept C2778186239 @default.
• W4385605208 hasConcept C2779446555 @default.
• W4385605208 hasConcept C2780035454 @default.
• W4385605208 hasConcept C2780069950 @default.
• W4385605208 hasConcept C54355233 @default.
• W4385605208 hasConcept C55105296 @default.
• W4385605208 hasConcept C60644358 @default.
• W4385605208 hasConcept C70721500 @default.
• W4385605208 hasConcept C71924100 @default.
• W4385605208 hasConcept C86803240 @default.
• W4385605208 hasConcept C98274493 @default.
• W4385605208 hasConceptScore W4385605208C104317684 @default.
• W4385605208 hasConceptScore W4385605208C118552586 @default.
• W4385605208 hasConceptScore W4385605208C142724271 @default.
• W4385605208 hasConceptScore W4385605208C155261790 @default.
• W4385605208 hasConceptScore W4385605208C204787440 @default.
• W4385605208 hasConceptScore W4385605208C2778186239 @default.
• W4385605208 hasConceptScore W4385605208C2779446555 @default.
• W4385605208 hasConceptScore W4385605208C2780035454 @default.
• W4385605208 hasConceptScore W4385605208C2780069950 @default.
• W4385605208 hasConceptScore W4385605208C54355233 @default.
• W4385605208 hasConceptScore W4385605208C55105296 @default.
• W4385605208 hasConceptScore W4385605208C60644358 @default.
• W4385605208 hasConceptScore W4385605208C70721500 @default.

• next