Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385606475> ?p ?o ?g. }
- W4385606475 abstract "Abstract Approximately 20% of aged captive giant pandas ( Ailuropoda melanoleuca ) have cataracts that impair their quality of life. To identify potential biomarkers of cataract formation, we carried out a quantitative proteomics analysis of 10 giant pandas to find proteins differing in abundance between healthy and cataract-bearing animals. We identified almost 150 proteins exceeding our threshold for differential abundance, most of which were associated with GO categories related to extracellular localization. The most significant differential abundance was associated with components of the proteasome and other proteins with a role in proteolysis or its regulation, most of which were depleted in pandas with cataracts. Other modulated proteins included components of the extracellular matrix or cytoskeleton, as well as associated signaling proteins and regulators, but we did not find any differentially expressed transcription factors. These results indicate that the formation of cataracts involves a complex post-transcriptional network of signaling inside and outside lens cells to drive stress responses as a means to address the accumulation of protein aggregates triggered by oxidative damage. The modulated proteins also indicate that it should be possible to predict the onset of cataracts in captive pandas by taking blood samples and testing them for the presence or absence of specific protein markers." @default.
- W4385606475 created "2023-08-06" @default.
- W4385606475 creator A5009868920 @default.
- W4385606475 creator A5012677271 @default.
- W4385606475 creator A5013342266 @default.
- W4385606475 creator A5014270585 @default.
- W4385606475 creator A5017941291 @default.
- W4385606475 creator A5021293751 @default.
- W4385606475 creator A5025389738 @default.
- W4385606475 creator A5027311139 @default.
- W4385606475 creator A5027933647 @default.
- W4385606475 creator A5037696799 @default.
- W4385606475 creator A5045885044 @default.
- W4385606475 creator A5046597133 @default.
- W4385606475 creator A5046796483 @default.
- W4385606475 creator A5047216770 @default.
- W4385606475 creator A5047365731 @default.
- W4385606475 creator A5049414075 @default.
- W4385606475 creator A5051862250 @default.
- W4385606475 creator A5056038993 @default.
- W4385606475 creator A5061190372 @default.
- W4385606475 creator A5063762384 @default.
- W4385606475 creator A5073127573 @default.
- W4385606475 creator A5078570515 @default.
- W4385606475 creator A5080841994 @default.
- W4385606475 creator A5089488563 @default.
- W4385606475 creator A5090520641 @default.
- W4385606475 creator A5057899651 @default.
- W4385606475 date "2023-08-05" @default.
- W4385606475 modified "2023-10-16" @default.
- W4385606475 title "Comparative proteomics in captive giant pandas to identify proteins involved in age-related cataract formation" @default.
- W4385606475 cites W1501698769 @default.
- W4385606475 cites W1573531091 @default.
- W4385606475 cites W1590772693 @default.
- W4385606475 cites W1823043228 @default.
- W4385606475 cites W1970843424 @default.
- W4385606475 cites W1973592885 @default.
- W4385606475 cites W1994986191 @default.
- W4385606475 cites W2009835186 @default.
- W4385606475 cites W2028070777 @default.
- W4385606475 cites W2036373599 @default.
- W4385606475 cites W2038326409 @default.
- W4385606475 cites W2048440254 @default.
- W4385606475 cites W2079559766 @default.
- W4385606475 cites W2080386870 @default.
- W4385606475 cites W2082937294 @default.
- W4385606475 cites W2086469366 @default.
- W4385606475 cites W2087144236 @default.
- W4385606475 cites W2094988753 @default.
- W4385606475 cites W2099709375 @default.
- W4385606475 cites W2108233815 @default.
- W4385606475 cites W2127012419 @default.
- W4385606475 cites W2128551987 @default.
- W4385606475 cites W2132014356 @default.
- W4385606475 cites W2145506361 @default.
- W4385606475 cites W2153446989 @default.
- W4385606475 cites W2159482845 @default.
- W4385606475 cites W2162021786 @default.
- W4385606475 cites W2271369835 @default.
- W4385606475 cites W2419236103 @default.
- W4385606475 cites W2478635969 @default.
- W4385606475 cites W2518514425 @default.
- W4385606475 cites W275309076 @default.
- W4385606475 cites W2889082981 @default.
- W4385606475 cites W2969718750 @default.
- W4385606475 cites W2975070845 @default.
- W4385606475 cites W2995129756 @default.
- W4385606475 cites W3034019369 @default.
- W4385606475 cites W3112448498 @default.
- W4385606475 cites W3210503887 @default.
- W4385606475 cites W4256409604 @default.
- W4385606475 cites W4307425304 @default.
- W4385606475 doi "https://doi.org/10.1038/s41598-023-40003-0" @default.
- W4385606475 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37543644" @default.
- W4385606475 hasPublicationYear "2023" @default.
- W4385606475 type Work @default.
- W4385606475 citedByCount "0" @default.
- W4385606475 crossrefType "journal-article" @default.
- W4385606475 hasAuthorship W4385606475A5009868920 @default.
- W4385606475 hasAuthorship W4385606475A5012677271 @default.
- W4385606475 hasAuthorship W4385606475A5013342266 @default.
- W4385606475 hasAuthorship W4385606475A5014270585 @default.
- W4385606475 hasAuthorship W4385606475A5017941291 @default.
- W4385606475 hasAuthorship W4385606475A5021293751 @default.
- W4385606475 hasAuthorship W4385606475A5025389738 @default.
- W4385606475 hasAuthorship W4385606475A5027311139 @default.
- W4385606475 hasAuthorship W4385606475A5027933647 @default.
- W4385606475 hasAuthorship W4385606475A5037696799 @default.
- W4385606475 hasAuthorship W4385606475A5045885044 @default.
- W4385606475 hasAuthorship W4385606475A5046597133 @default.
- W4385606475 hasAuthorship W4385606475A5046796483 @default.
- W4385606475 hasAuthorship W4385606475A5047216770 @default.
- W4385606475 hasAuthorship W4385606475A5047365731 @default.
- W4385606475 hasAuthorship W4385606475A5049414075 @default.
- W4385606475 hasAuthorship W4385606475A5051862250 @default.
- W4385606475 hasAuthorship W4385606475A5056038993 @default.
- W4385606475 hasAuthorship W4385606475A5057899651 @default.
- W4385606475 hasAuthorship W4385606475A5061190372 @default.
- W4385606475 hasAuthorship W4385606475A5063762384 @default.
- W4385606475 hasAuthorship W4385606475A5073127573 @default.