Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385606482> ?p ?o ?g. }
- W4385606482 endingPage "27" @default.
- W4385606482 startingPage "19" @default.
- W4385606482 abstract "Trichomonas gallinae is a protozoan parasite that is the causative agent of trichomoniasis, and infects captive and wild bird species throughout the world. Although metronidazole has been the drug of choice against trichomoniasis for decades, most Trichomonas gallinae strains have developed resistance. Therefore, drugs with new modes of action or targets are urgently needed. Here, we report the development and application of a cell-based CCK-8 method for the high-throughput screening and identification of new inhibitors of Trichomonas gallinae as a beginning point for the development of new treatments for trichomoniasis. We performed the high-throughput screening of 173 anti-parasitic compounds, and found 16 compounds that were potentially effective against Trichomonas gallinae. By measuring the median inhibitory concentration (IC50) and median cytotoxic concentration (CC50), we identified 3 potentially safe and effective compounds against Trichomonas gallinae: anisomycin, fumagillin, and MG132. In conclusion, this research successfully established a high-throughput screening method for compounds and identified 3 new safe and effective compounds against Trichomonas gallinae, providing a new treatment scheme for trichomoniasis." @default.
- W4385606482 created "2023-08-06" @default.
- W4385606482 creator A5002890531 @default.
- W4385606482 creator A5018881862 @default.
- W4385606482 creator A5019424179 @default.
- W4385606482 creator A5041184611 @default.
- W4385606482 creator A5041799910 @default.
- W4385606482 creator A5055563614 @default.
- W4385606482 creator A5064842058 @default.
- W4385606482 creator A5068355510 @default.
- W4385606482 creator A5090704794 @default.
- W4385606482 date "2023-12-01" @default.
- W4385606482 modified "2023-09-30" @default.
- W4385606482 title "Identification of new drug candidates against Trichomonas gallinae using high-throughput screening" @default.
- W4385606482 cites W1964506433 @default.
- W4385606482 cites W1964738265 @default.
- W4385606482 cites W1966498112 @default.
- W4385606482 cites W1967086390 @default.
- W4385606482 cites W1967316467 @default.
- W4385606482 cites W1972489358 @default.
- W4385606482 cites W1974825648 @default.
- W4385606482 cites W1986473904 @default.
- W4385606482 cites W1987303215 @default.
- W4385606482 cites W1990945181 @default.
- W4385606482 cites W1992102180 @default.
- W4385606482 cites W1993275154 @default.
- W4385606482 cites W1994359750 @default.
- W4385606482 cites W2026833441 @default.
- W4385606482 cites W2051039025 @default.
- W4385606482 cites W2052161010 @default.
- W4385606482 cites W2054028987 @default.
- W4385606482 cites W2054029713 @default.
- W4385606482 cites W2067888376 @default.
- W4385606482 cites W2085195730 @default.
- W4385606482 cites W2093313266 @default.
- W4385606482 cites W2096775177 @default.
- W4385606482 cites W2104237494 @default.
- W4385606482 cites W2114918609 @default.
- W4385606482 cites W2119101016 @default.
- W4385606482 cites W2121199243 @default.
- W4385606482 cites W2133138130 @default.
- W4385606482 cites W2138545508 @default.
- W4385606482 cites W2144748832 @default.
- W4385606482 cites W2145600860 @default.
- W4385606482 cites W2147705199 @default.
- W4385606482 cites W2147860656 @default.
- W4385606482 cites W2256548132 @default.
- W4385606482 cites W2322436739 @default.
- W4385606482 cites W2324809871 @default.
- W4385606482 cites W2333899172 @default.
- W4385606482 cites W2343189865 @default.
- W4385606482 cites W2525346346 @default.
- W4385606482 cites W2599086468 @default.
- W4385606482 cites W2614959142 @default.
- W4385606482 cites W2754854466 @default.
- W4385606482 cites W2790893163 @default.
- W4385606482 cites W2806297626 @default.
- W4385606482 cites W2886133077 @default.
- W4385606482 cites W2887766329 @default.
- W4385606482 cites W2888103883 @default.
- W4385606482 cites W2888362138 @default.
- W4385606482 cites W2901714246 @default.
- W4385606482 cites W2949711204 @default.
- W4385606482 cites W2966690388 @default.
- W4385606482 cites W2986198207 @default.
- W4385606482 cites W2999420944 @default.
- W4385606482 cites W3011235074 @default.
- W4385606482 cites W3016248999 @default.
- W4385606482 cites W3109840215 @default.
- W4385606482 cites W3124611822 @default.
- W4385606482 cites W3127175268 @default.
- W4385606482 cites W3188222819 @default.
- W4385606482 cites W3210084382 @default.
- W4385606482 cites W3215724470 @default.
- W4385606482 cites W4295008859 @default.
- W4385606482 doi "https://doi.org/10.1016/j.ijpddr.2023.08.001" @default.
- W4385606482 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37562241" @default.
- W4385606482 hasPublicationYear "2023" @default.
- W4385606482 type Work @default.
- W4385606482 citedByCount "0" @default.
- W4385606482 crossrefType "journal-article" @default.
- W4385606482 hasAuthorship W4385606482A5002890531 @default.
- W4385606482 hasAuthorship W4385606482A5018881862 @default.
- W4385606482 hasAuthorship W4385606482A5019424179 @default.
- W4385606482 hasAuthorship W4385606482A5041184611 @default.
- W4385606482 hasAuthorship W4385606482A5041799910 @default.
- W4385606482 hasAuthorship W4385606482A5055563614 @default.
- W4385606482 hasAuthorship W4385606482A5064842058 @default.
- W4385606482 hasAuthorship W4385606482A5068355510 @default.
- W4385606482 hasAuthorship W4385606482A5090704794 @default.
- W4385606482 hasBestOaLocation W43856064821 @default.
- W4385606482 hasConcept C136764020 @default.
- W4385606482 hasConcept C142724271 @default.
- W4385606482 hasConcept C2777023796 @default.
- W4385606482 hasConcept C2779397712 @default.
- W4385606482 hasConcept C2781114625 @default.
- W4385606482 hasConcept C3019792204 @default.
- W4385606482 hasConcept C41008148 @default.