FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385606522> ?p ?o ?g. }

• W4385606522 endingPage "100874" @default.
• W4385606522 startingPage "100874" @default.
• W4385606522 abstract "BackgroundHigh-density lipoprotein cholesterol (HDL-C) has been inversely associated with cardiovascular disease (CVD) risk, but recent evidence suggests that extremely high levels of HDL-C are paradoxically related to increased CVD incidence and mortality. This study aimed to comprehensively examine the associations of HDL-C with all-cause and cause-specific mortality in a Chinese population.MethodsThe China Health Evaluation And risk Reduction through nationwide Teamwork (ChinaHEART) project included 3,397,547 participants aged 35–75 years with a median follow-up of 3.9 years. Baseline HDL-C levels were measured, and mortality data was ascertained from the National Mortality Surveillance System and Vital Registration of Chinese Center for Disease Control and Prevention.FindingsThis study found U-shaped associations of HDL-C with all-cause, cardiovascular and cancer mortality. When compared with the groups with the lowest risk, the adjusted hazard ratios (95% CIs) for HDL-C <30 mg/dL was 1.23 (1.17–1.29), 1.33 (1.23–1.45) and 1.18 (1.09–1.28) for all-cause, CVD and cancer mortality, respectively. For HDL-C >90 mg/dL, the corresponding HR (95% CIs) was 1.10 (1.05–1.15), 1.09 (1.01–1.18) and 1.11 (1.03–1.19). Similar U-shaped patterns were also found in associations of HDL-C with ischemic heart disease, ischemic stroke, and liver cancer. About 3.25% of all-cause mortality could be attributed to abnormal levels of HDL-C. The major contributor to mortality was ischemic heart disease (16.06 deaths per 100,000 persons, 95% UI: 10.30–22.67) for HDL-C <40 mg/dL and esophageal cancer (2.29 deaths per 100,000 persons, 95% UI: 0.57–4.77) for HDL-C >70 mg/dL.InterpretationBoth low and high HDL-C were associated with increased mortality risk. We recommended 50–79 mg/dL as the optimal range of HDL-C among Chinese adults. Individuals with dyslipidemia might benefit from proper management of both low and high HDL-C.FundingThe CAMS Innovation Fund for Medical Science (2021-1-I2M-011), the National High Level Hospital Clinical Research Funding (2022-GSP-GG-4), the Ministry of Finance of China and National Health Commission of China, and the 111 Project from the Ministry of Education of China (B16005), the Program for Guangdong Introducing Innovative and Enterpreneurial Teams (2019ZT08Y481), Sanming Project of Medicine in Shenzhen (SZSM201811096), the Young Talent Program of the Academician Fund, Fuwai Hospital Chinese Academy of Medical Sciences, Shenzhen (YS-2022-006) and Guangdong Basic and Applied Basic Research Foundation (2023A1515010076 & 2021A1515220173)." @default.
• W4385606522 created "2023-08-06" @default.
• W4385606522 creator A5006350804 @default.
• W4385606522 creator A5007436656 @default.
• W4385606522 creator A5010743586 @default.
• W4385606522 creator A5013626210 @default.
• W4385606522 creator A5028581261 @default.
• W4385606522 creator A5032223758 @default.
• W4385606522 creator A5049692788 @default.
• W4385606522 creator A5051993838 @default.
• W4385606522 creator A5052137216 @default.
• W4385606522 creator A5060142050 @default.
• W4385606522 creator A5066292184 @default.
• W4385606522 creator A5071762492 @default.
• W4385606522 creator A5079924174 @default.
• W4385606522 creator A5081163695 @default.
• W4385606522 creator A5083570149 @default.
• W4385606522 creator A5086440545 @default.
• W4385606522 creator A5086664284 @default.
• W4385606522 date "2023-08-01" @default.
• W4385606522 modified "2023-10-18" @default.
• W4385606522 title "Association of high-density lipoprotein cholesterol with all-cause and cause-specific mortality in a Chinese population of 3.3 million adults: a prospective cohort study" @default.
• W4385606522 cites W2050672146 @default.
• W4385606522 cites W2103783427 @default.
• W4385606522 cites W2116404316 @default.
• W4385606522 cites W2120986848 @default.
• W4385606522 cites W2145813488 @default.
• W4385606522 cites W2146707618 @default.
• W4385606522 cites W2150959326 @default.
• W4385606522 cites W2159738130 @default.
• W4385606522 cites W2175680864 @default.
• W4385606522 cites W2417066833 @default.
• W4385606522 cites W2551615700 @default.
• W4385606522 cites W2606324234 @default.
• W4385606522 cites W2616536890 @default.
• W4385606522 cites W2762777606 @default.
• W4385606522 cites W2775150242 @default.
• W4385606522 cites W2786334390 @default.
• W4385606522 cites W2787647639 @default.
• W4385606522 cites W2789774760 @default.
• W4385606522 cites W2791944472 @default.
• W4385606522 cites W2900607304 @default.
• W4385606522 cites W2913059060 @default.
• W4385606522 cites W2953282350 @default.
• W4385606522 cites W3037244886 @default.
• W4385606522 cites W3091169259 @default.
• W4385606522 cites W3106075561 @default.
• W4385606522 cites W3111614883 @default.
• W4385606522 cites W3114721007 @default.
• W4385606522 cites W3143437408 @default.
• W4385606522 cites W3148937264 @default.
• W4385606522 cites W3203237957 @default.
• W4385606522 cites W4200109837 @default.
• W4385606522 cites W4282841534 @default.
• W4385606522 cites W4320492671 @default.
• W4385606522 cites W4378803859 @default.
• W4385606522 doi "https://doi.org/10.1016/j.lanwpc.2023.100874" @default.
• W4385606522 hasPublicationYear "2023" @default.
• W4385606522 type Work @default.
• W4385606522 citedByCount "0" @default.
• W4385606522 crossrefType "journal-article" @default.
• W4385606522 hasAuthorship W4385606522A5006350804 @default.
• W4385606522 hasAuthorship W4385606522A5007436656 @default.
• W4385606522 hasAuthorship W4385606522A5010743586 @default.
• W4385606522 hasAuthorship W4385606522A5013626210 @default.
• W4385606522 hasAuthorship W4385606522A5028581261 @default.
• W4385606522 hasAuthorship W4385606522A5032223758 @default.
• W4385606522 hasAuthorship W4385606522A5049692788 @default.
• W4385606522 hasAuthorship W4385606522A5051993838 @default.
• W4385606522 hasAuthorship W4385606522A5052137216 @default.
• W4385606522 hasAuthorship W4385606522A5060142050 @default.
• W4385606522 hasAuthorship W4385606522A5066292184 @default.
• W4385606522 hasAuthorship W4385606522A5071762492 @default.
• W4385606522 hasAuthorship W4385606522A5079924174 @default.
• W4385606522 hasAuthorship W4385606522A5081163695 @default.
• W4385606522 hasAuthorship W4385606522A5083570149 @default.
• W4385606522 hasAuthorship W4385606522A5086440545 @default.
• W4385606522 hasAuthorship W4385606522A5086664284 @default.
• W4385606522 hasBestOaLocation W43856065221 @default.
• W4385606522 hasConcept C120665830 @default.
• W4385606522 hasConcept C121332964 @default.
• W4385606522 hasConcept C126322002 @default.
• W4385606522 hasConcept C179755657 @default.
• W4385606522 hasConcept C207103383 @default.
• W4385606522 hasConcept C2778163477 @default.
• W4385606522 hasConcept C2779134260 @default.
• W4385606522 hasConcept C2908647359 @default.
• W4385606522 hasConcept C29374701 @default.
• W4385606522 hasConcept C44249647 @default.
• W4385606522 hasConcept C61511704 @default.
• W4385606522 hasConcept C71924100 @default.
• W4385606522 hasConcept C99454951 @default.
• W4385606522 hasConceptScore W4385606522C120665830 @default.
• W4385606522 hasConceptScore W4385606522C121332964 @default.
• W4385606522 hasConceptScore W4385606522C126322002 @default.
• W4385606522 hasConceptScore W4385606522C179755657 @default.
• W4385606522 hasConceptScore W4385606522C207103383 @default.
• W4385606522 hasConceptScore W4385606522C2778163477 @default.

• next