Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385606768> ?p ?o ?g. }
- W4385606768 abstract "Prevention of robust severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection in nasal turbinate (NT) requires in vivo evaluation of IgA neutralizing antibodies. Here, we report the efficacy of receptor binding domain (RBD)-specific monomeric B8-mIgA1 and B8-mIgA2, and dimeric B8-dIgA1, B8-dIgA2 and TH335-dIgA1 against intranasal SARS-CoV-2 challenge in Syrian hamsters. These antibodies exhibited comparable neutralization potency against authentic virus by competing with human angiotensin converting enzyme-2 (ACE2) receptor for RBD binding. While reducing viral loads in lungs significantly, prophylactic intranasal B8-dIgA unexpectedly led to high amount of infectious viruses and extended damage in NT compared to controls. Mechanistically, B8-dIgA failed to inhibit SARS-CoV-2 cell-to-cell transmission, but was hijacked by the virus through dendritic cell-mediated trans-infection of NT epithelia leading to robust nasal infection. Cryo-EM further revealed B8 as a class II antibody binding trimeric RBDs in 3-up or 2-up/1-down conformation. Neutralizing dIgA, therefore, may engage an unexpected mode of SARS-CoV-2 nasal infection and injury." @default.
- W4385606768 created "2023-08-06" @default.
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- W4385606768 date "2023-08-21" @default.
- W4385606768 modified "2023-10-01" @default.
- W4385606768 title "SARS-CoV-2 hijacks neutralizing dimeric IgA for nasal infection and injury in Syrian hamsters" @default.
- W4385606768 cites W1711743175 @default.
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- W4385606768 cites W2051298245 @default.
- W4385606768 cites W2054694911 @default.
- W4385606768 cites W2104456590 @default.
- W4385606768 cites W2140274822 @default.
- W4385606768 cites W2156643487 @default.
- W4385606768 cites W2162496804 @default.
- W4385606768 cites W2286326426 @default.
- W4385606768 cites W2327746020 @default.
- W4385606768 cites W2792882465 @default.
- W4385606768 cites W2915839491 @default.
- W4385606768 cites W2924905929 @default.
- W4385606768 cites W2984472267 @default.
- W4385606768 cites W3001897055 @default.
- W4385606768 cites W3002539152 @default.
- W4385606768 cites W3003217347 @default.
- W4385606768 cites W3004280078 @default.
- W4385606768 cites W3009219040 @default.
- W4385606768 cites W3009912996 @default.
- W4385606768 cites W3012831148 @default.
- W4385606768 cites W3014067025 @default.
- W4385606768 cites W3015190630 @default.
- W4385606768 cites W3016829967 @default.
- W4385606768 cites W3024602798 @default.
- W4385606768 cites W3029705204 @default.
- W4385606768 cites W3036190795 @default.
- W4385606768 cites W3038004004 @default.
- W4385606768 cites W3040725637 @default.
- W4385606768 cites W3041603492 @default.
- W4385606768 cites W3080999659 @default.
- W4385606768 cites W3087924281 @default.
- W4385606768 cites W3092136311 @default.
- W4385606768 cites W3092503590 @default.
- W4385606768 cites W3092921648 @default.
- W4385606768 cites W3093768302 @default.
- W4385606768 cites W3097426086 @default.
- W4385606768 cites W3112028440 @default.
- W4385606768 cites W3112389805 @default.
- W4385606768 cites W3114507428 @default.
- W4385606768 cites W3117759033 @default.
- W4385606768 cites W3131016929 @default.
- W4385606768 cites W3134888785 @default.
- W4385606768 cites W3135511673 @default.
- W4385606768 cites W3163104912 @default.
- W4385606768 cites W3163383906 @default.
- W4385606768 cites W3164087747 @default.
- W4385606768 cites W3164326780 @default.
- W4385606768 cites W3165073518 @default.
- W4385606768 cites W3170598451 @default.
- W4385606768 cites W3178565761 @default.
- W4385606768 cites W3196745706 @default.
- W4385606768 cites W4200004966 @default.
- W4385606768 cites W4210308999 @default.